d, Differential analysis of STARR-seq enhancer activity for each COF-AID cell line with and without IAA treatment to assess the effect of COF degradation on enhancer activity. Number of significantly up- or down-regulated enhancers is denoted (FDR ≤ 0.05). e, Log2 fold-change in ...
The murine gamma-herpesvirus-68 MK3 protein causes TAP degradation independent of MHC class I heavy chain degradation The murine gamma-herpesvirus-68 MK3 protein has an intricate interaction with the peptide loading complex that involves MK3 stabilization, a rapid degradat... Jessica M. Boname,Ja...
What are some examples of natural phenomena or processes that combine concepts from three of the following four concepts: physics, chemistry, mathematics, and biology? List five guidelines for living more sustainably. Describe an inherent problem in ecological and conservation biology in regard to expe...
Many recent researches have explored the relationship between m6A modification and TME infiltration, and this relationship cannot be well explained by RNA degradation. According to the report by Dali et al., this anti-tumor response of tumor-infiltrating CD8 + T cells is enhanced by the ...
A hydrophobic-tyrosine-any residue (HbYX) motif on the C-termini of proteasome-activating complexes independently triggers gate-opening of the 20S core particle for protein degradation; however, the causal allosteric mechanism remains unclear. Our study employs a structurally irreducible dipeptide HbYX ...
(NSAP1), ribosomal protein L13a (RPL13a), and GAPDH18,19,20. NSAP1 negatively regulates the RNA-binding function of EPRS1, L13a blocks ribosome recruitment through eIF4G interaction, and GAPDH protects L13a from degradation18. Interestingly, the TGEV GAIT-like element binds both EPRS1 and ...
degradation and depletion of tryptophan by IDO1 results in the suppression of T cell function. IHC, RT-PCR, flow cytometry, proliferation assay human FFPE and fresh tissue, mouse models Theate et al. (2015) Pilotte et al. (2012) TLR8 0.013039684 63 5 out of 8 Toll-like receptor 8 ...
The yeast plasma membrane, uracil permease, undergoes ubiquitin-dependent endocytosis and subsequent degradation in the vacuole via a process that does not... JM Galan,B Cantegrit,C Garnier,... - 《Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology》...
Although aggregation propensity based on protein structure was predicted to increase only modestly for the W407X nonsense mutation, the truncated protein it encodes might evade protein degradation machinery to form aggregate inclusions as noted by Smith et al.4. Mutations R320C and K430N conferred ...
ZNF140 and CENPF showed further increase in enrichment in basal BC beyond that seen in LP cells. YY1 has been implicated as promoting TNBC via a long noncoding RNA mechanism leading to degradation of PTEN66. The role of PROX1 in BC is not well described, but it belongs to a family of...