In our case this led to placing cells from Day 21 and 25 at the same level of the branching tree because most overlapped in terms of expression (See also Spring plot in Figure 3 and Figure S2). For similar reasons we grouped cells at D29 and D31 at the same level. After assigning ...
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In the highly pazopanib resistant MoJo cell line, NRASQ61R mutation sustained constitutive ERK activation. Transfection of the NRAS mutant in the pazopanib sensitive SYO-1 cell line increased the drug IC50. MoJo cells treatment with pazopanib in combination with the MEK inhibitor trametinib restored ...