(C) UMAP representation of a transcriptomic cell type taxonomy for the glutamatergic neuron types in mouse isocortex and hippocampal formation, revealing discrete and continuous variations (image adapted from Yao et al., 2021b). The basic architecture of the mammalian brain (Swanson, 2000, 2012) ...
We develop a Continuous State Hidden Markov model to identify the timing and type of signals, such as overexuberant Wnt responses, that induce some early multipotent NKX2-1+ progenitors to lose lung fate. Finally, we find that this initial developmental plasticity is regulatable and subsides over...
Task 1 is discrete repetition of the following subtask: grab the string at the colored section s; then, proceed grabbing the colored section s11 and repeat until the end of the string. Task 2 is nearly continuous repetition of the following subtask: cut around the circular pattern up to a...
Within the individual modules, the network sub-structure identifies genes with the highest degrees of correlation. To resolve whether these patterns linked to discrete cell states we re-ran the clustering and signature enrichment analysis for module genes independently. We defined the resulting sub-stru...