The Lentivirus human immunodeficiency virus (HIV) causes chronic inflammation and AIDS in humans, with variable rates of disease progression between individuals driven by both host and viral factors. Similarly, simian lentiviruses vary in their pathogeni
Concomitant analyses of six biomarkers, including FAP, CD29 (integrin-β1), α-SMA, FSP1, PDGFRβ, and caveolin, characterized four CAF subsets (from CAF-S1 to CAF-S4) with distinct properties in ovarian and breast cancers (BC) [94,98]. Kieffer et al. further identified eight different ...
The results of this subanalysis were consistent with those of the overall ARISTOTLE trial, with no significant interaction according to the presence or absence of valvular heart disease for both stroke and systemic embolism and major bleeding. In summary, exclusion criteria for concomitant valve ...
Both prior Mtb infection and BCG vaccination have been reported to confer some protection against subsequent infection and/or disease. However, the immune correlates of host protection with or without BCG vaccination remain poorly understood. Similarly, the host response to concomitant infection with ...
By contrast, only one of the three patients with R175H-mutant tumours had neopeptide reactivity; this patient (07E) had one of the largest expansions for the mutant TP53 allele and a concomitant increase in protein abundance as well as a positive response to anti-PD-L1 treatment (Fig. 3a...
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all patients experienced favorable clinical o
The percent of placebo-corrected changes from baseline for LDL-C (estimated by Friedewald calculation [Fc-LDL-C]) and HDL-C after 24 weeks of anacetrapib 100 mg/day were compared among patients by age, gender, race, diabetes status, type of concomitant statin with or without other lipid the...
Assessment includes infections, concomitant injury, medication and neurological classification usingAmerican Spinal Injury Associationimpairmentscale (AIS) and neurological level. Laboratory analyses comprise haematological profiling, immunophenotyping, including HLA-DR expression on monocytes, cytokines and gene ...
RT-PCR and Sanger sequencing confirmed that the morpholino design reduces normal splicing by >80%, leading to the inclusion of an intron adjacent to two different exons and a concomitant disruption of the Chd8 protein at aa604 and aa643 (Figure 4B). To examine the consequence of chd8 ...
Rebecca Fitzgerald and colleagues report the whole-genome sequences of 129 esophageal adenocarcinomas, showing frequent copy number alterations and prevalent mutations in receptor tyrosine kinases concomitant with mitogenic activation. They further chara