randomized clinical trials have shown that intravitreal injections of anti- vascular endothelial growth factor (anti-VEGF) agents are effective in reducing the macular thickness and improving the visual acuity in patients with DME.4–11 However, despite strict clinical trial protocol driven treatment cri...
This analysis included data from a worldwide, multicenter (153 centers), randomized, double-blind, placebo-controlled trial to assess the efficacy and safety profile of anacetrapib in patients with CHD or CHD risk equivalents (anacetrapib DEFINE protocol 019, Clinicaltrials.gov: NCT00685776).10 Deta...
Patients were enrolled in the PURE01 clinical trial, a Phase II prospective study of neoadjuvant pembrolizumab before radical cystectomy (NCT02736266). We used tumor samples from 82 patients as a biomarker-evaluable subset representative of the overall study cohort of 114 patients. The median follow-...
Depending on the results of these or future arms, data will be shared with larger clinical trial networks, including the Randomised Evaluation of COVID-19 Therapy trial (RECOVERY), and to other partners for rapid roll-out in larger patient cohorts. Trial registration number ISRCTN14212905 , NCT...
Screening and brief interventions for hazardous and harmful alcohol use in primary care: a cluster randomised controlled trial protocol p pBackground/p pThere have been many randomized controlled trials of screening and brief alcohol intervention in primary care. Most trials have reported p... E Ka...
Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial Science, 375 (2022), pp. 43-50 Google Scholar Glass et al., 2020 D.R. Glass, A.G. Tsai, J.P. Oliveria, F.J. Hartmann, S.C. Kimmey, A.A. Calderon, L. Borges, M.C. Glass, L.E. Wagar,...
• Data Type: integer, float, text, datetime, date, durationDatetime, parialDatetime • Controlled Terms/ISO Format • NCI Code/Extension • External Dictionary • Origin: CRF, Derived, Assigned, Protocol, eDT, Predecessor 2019 C3C Webinar Series How to Create Define-XML • Programming...
randomized, multi-center, multi-national, clinical trial on additional cerebral tissue oxygen saturation monitoring combined with defined treatment guidelines versus standard monitoring and treatment as usual in premature infants during immediate transition: study protocol for a randomized controlled trial [J...
The protocol consisted of antigen retrieval in a water bath at 98 °C using citrate buffer (pH 9.0, 20 min for TNC and NELL2; pH 6.0, 20 min for LAMA2). Detection of immunostaining was performed using the Envision rabbit/mouse detection system (K5007, Dako, Glostrup, Denmark) and ...
ethylenediaminetetraacetic acid (EDTA) (BD Bioscience). Cells were isolated by Ficoll-density centrifugation and frozen in fetal bovine serum with 5% dimethyl sulfoxide. Clinical data were captured in accordance with IRB protocol 20108117 at the time of informed consent and entered into the REDCap ...