Current thresholds to define chronic kidney disease (CKD) are essentially based on two measures, estimated GFR (eGFR) and albuminuria. The first two stages (stage 1 and 2) are mainly defined by the presence of abnormal albuminuria (>30 mg/g creatinine). Conversely, overt CKD (stages 3-5)...
229 kidney cells. Heritability analysis reveals that methylation variation explains a larger fraction of heritability than gene expression. We present a multi-stage prioritization strategy and prioritize target genes for 87% of kidney function loci. We highlight key roles of proximal tubules and ...
In total, we determined a panel of unique proteins and phosphoproteins as novel high-confidence candidates for disease biomarkers. Disease biomarkers will help diagnose whether a patient currently has PD. Our large-scale LC-MS analysis efforts combined with extensive bioinformatics analysis led to the...
In total, we determined a panel of unique proteins and phosphoproteins as novel high-confidence candidates for disease biomarkers. Disease biomarkers will help diagnose whether a patient currently has PD. Our large-scale LC-MS analysis efforts combined with extensive bioinformatics analysis led to the...
Western blots were performed for three proteins: alpha 1 antitrypsin, ceruloplasmin, and beta-2-microglobulin to confirm the variation in urine. For each protein, 16 normal human overnight urine samples (10 females and 6 males) were used. A urine sample from a stage IV diabetic nephropathy pat...
In a cross-sectional study, we compared the prevalence of anemia based on age- and gender-specific reference intervals for hemoglobin (Hgb) and hematocrit (Hct) with the Kidney Disease Outcomes Quality Initiative (KDOQI) anemia definition (Hgb 2 in patients with stage I CKD (n = 196)...
(Fig.3b). We then traced back the biopsy samples collected during the mid-stage (second hospitalization) of the disease (October, 2015). FFPE-biopsies taken from skin at the very beginning of the disease, clot, kidney and liver were positive for HHV-6 sncRNA-U14. These results point ...