Two of the strains ofN. bracarensiswere assembled using long read technology which provided a near chromosome level assembly. Using these genomes we performed a comparative analysis of adhesin presence inN. bracarensisandN. glabratus. Notably, when analysing the sequence of adhesins inN. bracaren...
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease Parker C. Wilson Amit Verma Benjamin D. Humphreys Genome Biology(2024) Associated content Linking genetic variants to kidney disease via the epigenome ...
(2007). Y- chromosome polymorphisms define the origin of the Mang, an isolated population in China. Ann Hum Biol 34:573-81.TAN;S;J;YANG;M;H;YU;H;J;et;al.Y-chromosome polymorphisms define the origin of the mang,an isolated population in china.Annals of Human Biology.2007...
Genetic variation and expression of m6A regulators in prostate cancer (A) Mutation spectrum of m6A regulators (B) The location of the m6A regulators on the chromosome (C) The CNV landscape of the 29 m6A regulators (D) Gene expression level of the 29 m6A regulators. * P < 0.05; **...
parent, and only one weakly significant term for the VIR parent: polytene chromosome puffing. The equivalent GO analysis of whole body RNA-Seq data returned significantly enriched terms for both aphid genotypes, including several for protein modification (Supplementary Material 6)....
Chromosome 1 and 19 contained the larg- est number of mutant genes in GBM C D105+ cell lines (Fig. 4B), however, the number of mutant genes distrib- uted differently between each cell line and chromosome. To explore common genome characteristics among the 5 different C D105+ ...
aSchematic of SARS-CoV-2 ΔN-EGFP replicon assembled in a hybrid BAC (bacterial artificial chromosome)/YAC (yeast artificial chromosome) system (top).bViral gene expression (EGFP) in 293 T cells transfected with replicon.cEPRS1 immunoprecipitation (IP) from flow-sorted GFP+cells validated by...
Although levels of RING1B were unchanged, knockdown of RYBP in HEK293 cells led to a dramatic reduction in H2AK119ub1 level but no changes in H3K27me3 (Figure 6E). Together with our finding that RYBP-containing complexes have greater ubiquitinating activity than the canonical PRC1 (Figure...
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we applied bulk, single-cell and sin
The ability of tubulin monomers to self-assemble into large polymers in the presence of GTP, and to disassemble upon GTP hydrolysis, is an essential characteristic of microtubule dynamics, and is critical to many biological processes such as cell motility, mitotic chromosome segregation, and ...