Genome-wide expression profiling identified five biological BC subtypes36, namely luminal A/B, HER2-enriched, basal-like and normal breast-like, which differ by hormonal receptor status, proliferation, genomic instability, mutational signatures, treatment response and prognosis37,38,39,40,41. It has...
Our work provides the largest to date exploration of genetic influences on cell morphology (what we term cmQTLs). Where previous studies have been limited by both sample size and the scale of morphological measurements, we combined whole genome sequence analysis with Cell Painting to define relation...
OnJuly 9, 2024ByTony Kendzior, CLU, ChFC - Financial PlannerInFinancial Planning,HealthCare,Investment Planning,Long-term Care,Personal,Retirement Planning,Wills and Trusts My Comments: Our lives inevitably come to an end at some point. The question for all of us is what happens to the stuff...
The frequently used term “predict the prognosis” in many biomarker studies may confuse readers of the accurate definition for these two types of biomarkers. Specifically, a predictive biomarker differentiates treatment-specific survival benefits in biomarker-positive or biomarker-negative patients20and fur...
Postsynaptic density (PSD) proteins have been implicated in the pathophysiology of neurodevelopmental and psychiatric disorders. Here, we present detailed clinical and genetic data for 20 patients with likely gene-disrupting mutations in TANC2—whose pro
Table 2. ISH Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: ASCO-CAP Guideline Update. In clinical practice, these guidelines have been used to discriminate HER2-negative BCs from HER2-positive BCs, the latter being eligible for target therapy with anti-HER2 monoclonal antibod...
Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas: Subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072. Ann. Oncol. 2014, 25, 719–724. [CrossRef] 20. Imura, Y.; Nakai, T.; Yamada, S.; ...