We set out to study the open chromatin profile of human subcutaneous white adipose tissue (WAT), using abdominal (A) and gluteofemoral (GF) depot-derived preadipocytes isolated from two obese apple-shaped women (age = 33 ± 2.3 years, BMI = 34 ± 1.4 kg/m2, waist to...
Red bars depict the recognition frequency in ex vivo analyses whereas the white bars indicate the frequency after a 12-d pre-stimulation. c–f, Intensity of T cell responses in terms of calculated spot counts against the (c,d) cross-reactive and (e,f) SARS-CoV-2-specific (c,e) HLA ...
The small sample size limited this analysis in an unbiased manner. Therefore, we performed further targeted analysis of the predefined DEGs (Tables S3 and S5) using DESeq2 with a design including interaction terms as outlined in the methods. Focusing on the responders at PRE, 18 shared DEGs ...
MMR status was the strongest predictor of microbial community variance in comparison to sample location (proximal/distal and on/off tumor), body mass index (BMI), age, and sex. Separate analyses of the dMMR and pMMR microbial communities revealed that many common CRC-associated microbial ...
Despite some overlap in gene targets by different PCGFs, the functional terms associated with PCGF-enriched regions according to GREAT (McLean et al., 2010) were very different (Figure 2C), suggesting that the chromatin distribution of each PCGF reflects functional differences. PCGF1 target genes...
We defined improvement as a reduction in drug dose for the treatment of weight-related disorders. Weight progression was assessed in terms of BMI, weight loss, expressed (1) as a percentage of excess body mass index loss (% EBMIL), (2) percentage of total weight loss (% TWL), and (3...
Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy 5 Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway 6 Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University...