“In science, we define ‘creativity’ as an idea that is novel, good, and useful. It’s a little broader than the Oxford Dictionary’s definition, where it’s just the ability to create, because that doesn’t really say much. You can create something and it’s not very useful or it...
Interestingly, K14 expression did not show an expression bias towards invasive modes in the PDOs or their corresponding primary tissues (Supplementary Fig. 1A), indicating that a more complex cellular wiring creates diverse invasion. We also assessed the invasive patterns of four additional HNSCC P...
Osteosarcoma is a primary bone malignancy most prevalent in adolescents and young adults, with a second peak in later adulthood. While chemotherapy with the standard cisplatin/doxorubicin/methotrexate regimen (known as MAP), combined with surgical resection has markedly improved prognosis in patients with...
However, because it is a requirement in Australia that all patients with advanced melanoma have melanoma tissue tested for BRAF mutations prior to commencing any drug therapy, the impact of selection bias in this study is minimized as all patients have pre-treatment biopsies taken. Patient response...
Acta Neuropathologica Communications (2016) 4:88 DOI 10.1186/s40478-016-0349-9 RESEARCH Open Access Chromosome 1q gain and tenascin-C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma Asuka Araki1,6,7,8, Monika Chocholous2,6, Johannes Gojo...
3.2. Two naturally occurring mutants exhibit distinct signaling bias To characterize two newly identified naturally occurring mutants, we used site-directed mutagenesis to construct expression vectors containing these two point mutations. After transfection in HEK293 cells, both wild-type (GPR103-WT) and...
This factor is not the result of even the consummate skills of our perfumers at Alpha Aromatics, and is totally based in human biology; namely the olfactory receptors that are directly linked to the part of the human brain known as the limbic system, which control memory and emotion. How ...
quality = 25, variant supporting reads mapped to both strands, and strand bias no greater than 10%. CNV detection was using a self-developed pipeline, which has been validated in 38 samples against their droplet digital polymerase chain reaction (ddPCR) results as “gold standard”. The ...
This analysis shows that despite the strong 3’ bias, 10X RNA-seq data can also be used for cell clustering by SCASL. As discussed previously in the manuscript, the information of cell identities supplied by AS profiles are highly redundant, and therefore, fractions of the AS profiles within...
Richard A, Lyons P, Peters J, Biasci D, Flint S, Lee J, et al. Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation. BMC Genomics. 2014;15(1):649. Article PubMed PubMed Central Google Scholar Yang YH, Dudoit S, Luu P, Lin...