Gal-4 is enriched at the membrane of the nascent axon28, and is secreted by non-classical mechanisms to the extracellular milieu, where it keeps oligodendrocyte precursors (OLPs) in their undifferentiated proliferative state, unable to synthesize myelin27. As neurons progress through the different d...
The importance of tubulins for long-axon infrastructure, and the special morphology and function of motor neurons, underscore the central role of the cytoskeleton. The recent linkage of mutations to the tubulin α chain, TUBA4A, to familial and sporadic cases of ALS provides a new investigative ...
Biology of human development Developmental biology Natural sciences Omics Transcriptomics Sorry, something went wrong. Please try again and make sure cookies are enabledReferences 1 Y. Yamanaka, O.J. Tamplin, A. Beckers, A. Gossler, J. Rossant Live imaging and genetic analysis of mouse notochord...
Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axisChondroitin sulfate (CS) and heparan sulfate (HS) are glycosaminoglycans that both bind the receptor-type protein tyrosine phosphatase PTPRσ, affecting axonal regeneration. CS inhibits axonal growth, while HS ...
were strongly associated with semaphorin-plexin signaling pathway, negative chemotaxis, negative regulation of axon extension in axon guidance, negative regulation of endopeptidase activity, regulation of cell growth, negative regulation of peptidase activity, cell migration, wound healing, and axon guidance...
A synapse is a junction where the wire-like axon of one neuron meets the branched dendrites of another. Information, in the form of chemical signals called neurotransmitters, is passed between neurons across these synapses. "We wanted to know if these interacting proteins on the surface of neuro...
To explore these possibilities, we cultured VD4 neurons alone or with VF and/or RPeD1 postsynaptic targets in CM or DM, using an axon-axon configuration to facilitate visualization of synaptic sites. Using immunocytochemistry (ICC) and an antibody against the RF-NH2 moiety common to FMRF ...
During development, there is a distinction between medial and lateral floor plate: medial cells express Shh, axon guidance molecule netrin-1 and the transcription factor forkhead box A2, and lateral cells express a subset of these factors and other markers35. This medial–lateral floor-plate ...
Zebrafish TrkC1 and TrkC2 receptors define two different cell populations in the nervous system during the period of axonogenesis. Developmental Biology. 1998; 195 :114–130. doi: 10.1006/dbio.1997.8839. [ Cross Ref ]Martin SC, Sandell JH, Heinrich G (1998) Zebrafish TrkC1 and TrkC2 ...