Biomarkers in amyotrophic lateral sclerosis: combining metabolomic and clinical parameters to define disease progression. Eur J Neurol 2016; 23: 346-53.Blasco H, Nadal-Desbarats L, Pradat PF, Gordon PH, Madji Hounoum B, Patin F, et al. Biomarkers in amyotrophic lateral sclerosis: combining ...
We investigated the use of immunostaining with antibodies to tau, ubiquitin, and alpha B-crystallin in defining a protocol for the staged neuropathologic examination of brains from patients with a progressive frontotemporal dementia.Brains obtained from 50 patients dying with the clinical diagnosis of ...
(2015) Review of Amyotrophic Lateral Sclerosis, Parkinson’s and Alzheimer’s diseases helps further define pathology of the novel paradigm for Alzheimer’s with heavy metals as primary disease cause. Medical Hypotheses 85 , 779-790 /Cavaleri, F., 2015. Review of Amyotrophic Lateral Sclerosis, ...
Atypical form of amyotrophic lateral sclerosis: a new term to define a previously known form of ALS. J Neurol Neurosurg Psychiatry 2000; 68: 118-9.Gamez J, Cervera C, Codina A (2000). Atypical form of amyotrophic lateral sclerosis: a new term to define a previously known form of ALS. ...
Amyotrophic lateral sclerosis (ALS) is an inexorably progressive and degenerative disorder of motor neurons with no currently-known cure. Studies to determine the mechanism of neurotoxicity and the impact of ALS-linked mutations (,,,and others) have greatly expanded our knowledge of ALS disease mecha...
showed that non-invasive ventilation (NIV) improved quality of life and extended survival in amyotrophic lateral sclerosis (ALS) patients (1). However, NIV did not increase survival in patients with poor bulbar function, and the study did not specify minimum duration of NIV use, or the ...
doi:10.1016/j.mehy.2016.10.022Franco CavaleriESMedical Hypotheses
Neuronal cytoplasmic inclusions (NCIs) containing phosphorylated TDP-43 (p-TDP-43) are the pathological hallmarks of motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) and FTLD-TDP. The vast majority of NCIs in the brain and spinal cord also label for ubiquitin and p62, however, we ...