Four contiguous amino acids define the target for streptolydigin resistance in the beta subunit of Escherichia coli RNA polymerase - Heisler, Suzuki, et al. - 1993Heisler LM, Suzuki H, Landick R, Gross C. 1993. Four contiguous amino acids define the target for streptolydigin resistance in...
George Obiero2, Philip Bejon1,3, Jean Langhorne4, Abdirahman Abdi1 and Lynette Isabella Ochola‑Oyier1* Abstract Background Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections...
Drug resistance is frequently caused by DNA single nucleotide variants (SNVs) in the cancer genome2, leading to point mutations in the drug target or proteins within the same signaling pathway3. The study of drug resistance can inform drug mechanism of action, the design of second-generation ...
GAIT-like VAIT (virus-activated inhibitor of translation) elements have been described in non-terminal regions of the SARS-CoV-2 genome, that bind RPL13a like GAIT leading to target-specific repression21. However, little is known about pan-virus RNA post-transcriptional...
George Obiero2, Philip Bejon1,3, Jean Langhorne4, Abdirahman Abdi1 and Lynette Isabella Ochola‑Oyier1* Abstract Background Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections...
Can messenger RNA code for multiple proteins? How are messenger RNA and transfer RNA similar? Do amino acids use messenger RNA? What enzyme transcribes DNA into messenger RNA? In which organelle is messenger RNA made? How is messenger RNA processed before leaving the eukaryotic cell? How does ...
(26 RCC patients and 33 LCC patients) were extracted from the multi-omics cohort in our tissue biobank, and WES and RNA-seq of the tumor samples were performed to obtain genomic expression patterns related to each tumor location. The multi-omics results are summarized in the Taxa, Metabolites...
Part of the DNA has ATGGCAGTC. What is the anti-codon of this stand? Why is a codon made of 3, and not 4, nucleotides? Explain what mRNA is and rRNA is. What does each codon in messenger RNA (mRNA) specify? a. a nucleotide b. an enzyme c. an amino acid d. a promotor What...
There is a lack of well validated prognostic biomarkers in osteosarcoma, a rare, recalcitrant disease for which treatment standards have not changed in over 20 years. We performed microRNA sequencing in 74 frozen osteosarcoma biopsy samples, constituting
DNA was extracted from cell pellets (Qiagen) and the gRNA cassette was PCR amplified (PCR1, 28 cycles, 3 µg per reaction) with several reactions in parallel to maintain the complexity of the library. After column purification of PCR1 products (Qiagen), PCR products were indexed by PCR...