Define affinity, efficacy, and potency. Briefly explain the relationship among them. Briefly describe the impact the invention of the microscope has had on biology. Explain the importance of water in biology. Explain the meaning of the term Double-blind as used in Biology. ...
Electronegativity goes on decreasing down the group. It goes on increasing along the period from left to right.
It has also been shown to be elevated in the preclinical stage of sporadic AD and is increased in both AD CSF and plasma by affinity-based proteomic measurement46,47. SMOC1 is therefore a promising biofluid AD biomarker of brain Aβ deposition that may be particularly useful in the context ...
We hypothesize that binding to composite motifs in which at least two SMAD binding sites are in close proximity would be enough to induce transcription as this scenario allows the simultaneous interaction of at least two SMAD proteins, thereby increasing specificity and affinity. Results: Using more...
Reversible or quasi-reversible fluorescent probes: This method is similar to the above method of bimolecular complementation but depends on usage of protein fragments that have very low intrinsic affinity of the two halves of the fluorophore. So far, two types of such probes have been utilized for...
2a). We further looked to capture variation in mutant p53 concentration, which affects both the transcription factor function and neoantigen presentation. We assigned TCGA samples a normalized p53 protein concentration and effective MDM2 promoter affinity to infer typical per-allele mutant-specific ...
Define affinity, efficacy, and potency. Briefly explain the relationship among them. Describe the significance of p53. Provide a hypothesis of research that could be conducted to further investigate the effectiveness of p53. Explain validity and give an example. What is the more realistic method of...
Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal component of the tumor microenvironment. The versatil
The results presented here define the active site fold and catalytic residues of hGH and should facilitate the design of high affinity inhibitors specific for GH to test whether inhibition of GH activity would lead to increased retention of folyl- and antifolylpolyglutamates within the cell. ...
(reflexive) To have a strong affinity with; to feel oneself to be modelled on or connected to. Define To describe, explain, or make definite and clear; used to request the listener or other person to elaborate or explain more clearly his or her intended meaning of a word or expression. ...