Sarah Roller
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol, 28 (22) (2010), pp. 3636-3643 Google Scholar 32 F Delhommeau...
Relapse following conventional treatment is the single most adverse event in medulloblastoma; over 95% of relapsing patients die, accounting for ∼10% of childhood cancer deaths (Pizer and Clifford, 2009). Biological investigations have to date focused on the disease at diagnosis, where disease-wid...
) That which is, or may be, presented in opposition; an adverse reason or argument; a reason for objecting; obstacle; impediment; as, I have no objection to going; unreasonable objections. Objection (n.) Cause of trouble; sorrow. Objectionable (a.) Liable to objection; likely to be ...
(NIR-PIT), a new and novel method to remove CAFs. This approach inhibited tumor growth in a co-cultured human esophageal squamous cell carcinoma xenograft model without adverse effects. So far, the FDA (Food and Drug Administration) has approved five CAR-T therapies for hematological ...
drug developmentsObjective : The first goal of phase I drug development is the determination of maximal tolerated dose, which must be established by case-by-case analysis, sometimes using a laboratory adverse event. Since no accurate rule defining lab adverse events, has been validated yet, we ...
Major Adverse Cardiac EventOptimal treatment of patients who present with chest pain is predicated on accurate identification of those patients with a cardiac etiology of their discomfort. Serial troponins and electrocardiograms are very sensitive for the detection of myocardial infarction but they are ...
Anacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that raises HDL-C and reduces LDL-C when administered alone or with a statin. Adverse effects on blood pressure, electrolytes, and aldosterone levels, seen with another drug in this class, have not been noted in studies of ...