DEFINING BURKITT‐LIKE LYMPHOMA WITH 11Q ABERRATION IN A SPECIALISED UK HAEMATOPATHOLOGY DIAGNOSTIC SERVICE Introduction: A subset of aggressive lymphomas that have similar clinicopathological features to sporadic Burkitt lymphoma (BL), lack the hallmark MYC gene rearrangement that typifies BL, and are ch...
In intracranial ependymomas gain of chromosome 1q is a frequent genomic aberration. It could be detected in up to 24 % of all pediatric cases [13, 17, 23–26], whereas it was found only in 8 % of adult patients in a metanaly- sis [22]. In line with these previous findings we ...
High-throughput techniques have been used to analyze the global genome and transcriptome profiles of meningiomas with interesting insights into the biology of meningiomas [11–15]. However, these studies have either surveyed limited number of genes [14, 15], analyzed limited number of samples [11]...
Suppression of SOX2 expression in SCLC with SOX2 amplification resulted in an inhibition of tumor growth [10]. Recent studies support an important role for SOX2 in SCLC biology. Voigt et al. have shown that in SCLC, the genetic inactivation of RB1 is responsible for the upregulation of SOX2...