We next compared the gene expression and chromatin accessibility of polyp and CRC stem-like cells with normal stem cells to identify the aberrant gene expression and regulatory programs in precancerous and cancerous lesions. After computing differential peaks between stem-like cells from each sample ...
We next compared the gene expression and chromatin accessibility of polyp and CRC stem-like cells with normal stem cells to identify the aberrant gene expression and regulatory programs in precancerous and cancerous lesions. After computing differential peaks between stem-like cells from each sample ...
The absence of clathrin at endosomes results in aberrant ILV formation. a Budding profiles as observed in electron micrographs were binned into three morphological categories: Pits, U-shaped buds and omega-shaped buds (see also Supplementary Fig. 8). The outlines of these budding profiles were ali...
Conversely, an excess of Mec1kd in MEC1 cells does not abrogate the G(2)/M checkpoint, suggesting that Mec1 functions required for response to aberrant DNA structures during specific cell cycle stages can be separable. In agreement ... V Paciotti,M Clerici,M Scotti,... - 《Molecular &...
Understanding how distinct cell types arise from multipotent progenitor cells is a major quest in stem cell biology. The liver and pancreas share many aspects of their early development and possibly originate from a common progenitor. However, how liver and pancreas cells diverge from a common endod...
Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations Cell Death Differ., 21 (2014), pp. 978-989 CrossrefView in ScopusGoogle Scholar Nikolić et al., 2017 M.Z. Nikolić...
Inserm U892; CNRS 6299 and Angers University; Angers, France Keywords: STAT3, chemotherapy, targeted therapy, resistance, NFκB Aberrant activation of the STAT3 transcription factor has been reported in a large group of tumors and a strong biological basis now defines thi...
Aberrant activation of the STAT3 transcription factor has been reported in a large group of tumors and a strong biological basis now defines this protein as an oncogenic driver. Consequently, STAT3 is considered to be a promising target in the field of cancer therapy. For its inhibition to resul...
Article Open access 23 March 2021 Computational epigenetic landscape analysis reveals association of CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 lncRNAs in prostate cancer progression through aberrant methylation Article Open access 17 June 2022 Introduction...
BRCA1mutation carriers have been shown to harbor an expanded population of luminal progenitor cells with an aberrant phenotype, including expression of some basal epithelial cell markers44,45. Gene expression profiling fromBRCA1heterozygous breast tissue showed similarities between luminal progenitor cells ...