FALC stromal cells define a unique immunological niche for the surveillance of serous cavitiesThe serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities ...
Mechanistically, this MAP3K2 specific function is mediated by a previously unknown reactive oxygen species (ROS)–MAP3K2–ERK5–KLF2 axis to enhance production of R-spondin 1. Our results identify MRISCs as a key component of an intestinal stem cell niche that specifically depends on MAP3K2 ...
5a)23. This cluster of fibroblasts exhibited the highest expression of RSPO3, a factor that supports the intestinal stem cell niche24. We also observe a cluster of cancer-associated fibroblasts (CAFs) consisting almost exclusively of cells from CRCs, and a scATAC cluster of fibroblasts enriched ...
ERM is required for transcriptional control of the spermatogonial stem cell niche stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome... C Chen,W Ouyang,V Grigura,... - 《Nature》 被引量:...
内容提示: 606 | Nature | Vol 592 | 22 April 2021ArticleMAP3K2-regulated intestinal stromal cells define a distinct stem cell nicheNingbo Wu 1,2,12 , Hongxiang Sun 1,2,12 , Xiaoyun Zhao 1,2 , Yao Zhang 1,3 , Jianmei Tan 1,2 , Yuanyuan Qi 1 , Qun Wang 1 , Melissa Ng 4 ,...
Furthermore, this study characterizes regulators of cell-fate decision and matrisome enriched in the notochordal niche. Importantly, we identify specific cell-surface markers opening avenues for differentiation refinement, NC purification, and functional studies. Altogether, this study provides a human ...
p>A primary goal of many next-generation bioenergy systems is to increase ecosystem services such as soil carbon (C) storage and nutrient retention. Evalua... EM Bach,KS Hofmockel - 《Global Change Biology Bioenergy》 被引量: 15发表: 2016年 Evolving the 'DNA blueprint' of eNetwork middlewa...
Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. 2004. p. 131:3423–3432. doi:10.1242/dev.01202. 42. Herold-Mende C, Mueller MM, Bonsanto MM, Schmitt HP, Kunze S, Steiner HH. Clinical impact and functional aspects of ...
Microbial consortia composed of autotrophic and heterotrophic species abound in nature, yet examples of synthetic communities with mixed metabolism are limited in the laboratory. We previously engineered a model cyanobacterium, Synechococcus elongatus PC
Sato, T. et al. Single Lgr5 stem cells build crypt-villus structuresin vitrowithout a mesenchymal niche.Nature459, 262–265 (2009). CASPubMedGoogle Scholar Ciriello, G. et al. Emerging landscape of oncogenic signatures across human cancers.Nat. Genet.45, 1127–1133 (2013). ...