Fig. 1: Single-cell atlas of expression and chromatin accessibility in CRC development. a, Summary of the samples in this study. The bar chart shows the number of normal/unaffected colon tissues (gray), adenomas (purple) and CRCs (red) assayed for each patient. Locations of samples assayed...
Fig. 1: Single-cell atlas of expression and chromatin accessibility in CRC development. a, Summary of the samples in this study. The bar chart shows the number of normal/unaffected colon tissues (gray), adenomas (purple) and CRCs (red) assayed for each patient. Locations of samples assayed...
a, Summary of benign breast duct cell types and BC subtypes. The image was created with BioRender.com.b, Sample grid processing method utilized in the study to perform various assays on each tumor sample systematically.c, Summary of data types available for single-cell, single-nucleus and ST ...
Immune checkpoint inhibitors have transformed the treatment landscape of non-small cell lung cancer (NSCLC). However, accurately identifying patients who will benefit from immunotherapy remains a challenge. This study aimed to discover potential biomarke
One can define a tree of cell types for each species, covering its entire life span, and compare such trees across species. Obviously, the “tree” will be a very complex, multi-dimensional graph, and there will likely be multiple branches connecting each node to account for convergence, ...
(scRNA-seq) can provide a detailed picture of cell states, distinguishing between immature and fully differentiated PSC-derived cells, this technique alone loses information about spatial and temporal factors and can only imply cell parent-progeny relationships in the absence of a lineage tracing ...
HLA/MHC class II molecules show high degree of polymorphism in the human population. The individual polymorphic motifs have been suggested to be propagated and mixed by transfer of genetic material (recombination, gene conversion) between alleles, but no
Glioma stem like cells (GSC) represent the highest cellular hierarchy in GBM and have a determining role in tumor growth, recurrence and patient prognosis. However, a better definition of GSC subpopulations, especially at the surgical resection margin, is warranted for improved oncological treatment ...
SCASL employs spectral clustering, a graph-based clustering algorithm29, with the modified AS probability matrix above. The elbow method is implemented to help determine the optimal number of clusters30. To showcase its performance, SCASL was applied to 6 sets of single-cell transcriptome data ge...
of its maximum, respectively (please see methods for details), this analysis evidences that the average Gal-4 expression (Fig.1g, bar graph) in non-myelinated axon segments is significantly higher (70%; black bar) than that of myelinated ones (25%; gray bar), in agreement with our ...