We confirmed the absence of APN in CSF by dot-blot immunoassay. The aged APN-KO mice had spatial memory impairments and anxiety. Remarkably, the mice also displayed AD-like pathologies including Aβ oligomers accumulation, Tau hyperphosphorylation, neuroinflammation and possibly synaptic loss. Our ...
Given that either iodine deficiency or excess could lead to severe thyroid disorders, iodine content in drinking water should obviously remain within a certain range. Owing to the absence of data on iodine RfD in the Integrated Risk Information System (IRIS) database of the USEPA, the lower an...
In the absence of phytoplankton and under circumstances of forced high allochthony, the carbohydrate content of herbivorous zooplankton increased from ~6 even up to 10% of TOC, reflecting the poor biochemical quality of terrestrial organic matter. We found that when algal food availability is low,...
2A). The effect of the absence of KCa3.1 on reactive astrocytes in LPS-induced mice was investigated by immunostaining for GFAP. As shown in Fig. 2B, the GFAP immunoreactivity in the hippocampus was higher in WT + LPS mice than in WT controls, but was lower in KO + LPS mice...
Taken together these data indicate that per- ipheral injection of LPS causes morphological changes in microglia that are consistent with protracted activa- tion and this occurs in the absence of increased neuro- nal death. Discussion We have previously reported that stimulation of the per- ipheral...
letters indicate the regeneration of NAD(P)+from NAD(P)H. In rice plants, the blue pathways contribute to their tolerance to long-term O2deficiency compared with the terrestrial plants. Some wetland plants such as rice also have a high ability to optimally regulate the pyruvate level by ...
Functional tests show the absence of a glycemic response and an aggravation of hyperlactacidemia after injection of glucagon (1 mg/m2 of body surface) in a fasting patient or 2 hours after a meal rich in carbohydrates. Galactose injection (1 g/kg) neither induces hyperglycemia nor corrects the...
(F) The expression of I-Abα- and β-chain in magnetically purified splenic B cells of the indicated mouse strains was analyzed by qRT-PCR after overnight culture in the presence or absence of 10 μg/mL LPS. Analysis of β-actin expression was used for standardization. Shown are ...
These results suggest that short-term isolated zinc deficiency impairs growth, diges- tion, and absorption in the rat small intestine, even in the absence of associated protein calorie malnutrition. (Pediatr Res 19: 1333-1336,1985) those found in the small intestinal mucosa. For example, the ...
1B). These data suggest, however, that the lack of α-T caused increased oxidative stress leading to increased AA depletion. Uric acid is a powerful antioxidant, and, like glutathione, has been hypothesized to increase in the absence of AA as a compensatory antioxidant mechanism (26). ...