背景 复杂疾病(complex disease)也称为多基因病(polygenicdisease),通常是由遗传因素、环境因素和其他因素共同作用导致的,一般涉及多个基因,如高血压、糖尿病、心血管病等均属于复杂疾病的范畴。复杂疾病在人群中发病率较高,并且具有明显遗传易感性,但对于大部分复...
(C-0),and the polygenic heritability in segregating generations (B1,B2,F2) was 47.9002%,31.4338% and 56.8436% respectively,and environmental variance accounted for a larger proportion of the phenotypic variance,which was more than 40%.It's found that the hypocotyl length of cucumber was mainly ...
摘要:For decades, people have used genetic information to exercise control over the kinds of children they will have. These technologies have largely targeted chromosomal and monogenic disorders and traits; but most human phenotypes are highly polygenic (and influenced by the environment). One technolo...
4. Liebers DT, Pirooznia M, Ganna A et al. Discriminating bipolar depression from major depressive disorder with polygenic risk scores. Psychol Med, 2020:1-8. 5. Lewis KJS, Richards A, Karlsson R, et al. Comparison of Genetic Liability...
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated th...