In the present study, we focused on the tumor-suppressive role of TGFBR3 in advanced ccRCC. On the basis of results using an in vivo renal orthotopic tumor model, we hypothesized that the loss of TGFBR3 enhances multiple metastatic abilities of ccRCC cells. Loss of TGFBR3 increased the CIC-...
847. Intracardiac Injection of a Capsid-Modified Ad5/35 Results in Decreased Heart Toxicity When Compared to Standard Ad5 None - 《Molecular Therapy》 被引量: 0发表: 2009年 Attenuation of Hypertension and Heart Hypertrophy by Adeno-Associated Virus Delivering Angiotensinogen Antisense Using a model ...
Furthermore, attenuation of p21 results in augmentation of cell cycle transit in vitro. Thus, levels of p21 are inversely correlated with renal tubular epithelial cell proliferation. Roscovitine, which has been shown to arrest progression in a murine model of PKD, increases p21 levels and decreases...
These results are consistent with the development of tolerance to ISDN-SR. Although there was significant attenuation of exercise diastolic blood pressure with both drugs after a single dose, this result was sustained after 2 weeks of treatment only in the ISMN group. Headache was the only ...
RESULTS Patient characteristics The clinical characteristics of the study participants are shown in Table 1. There were no statistically significant differences in terms of maternal age, gestational age at blood sampling and the percentage of smokers between the two study groups. The pre-pregnancy body...
Pgc-1α overexpression alone, in the absence of MPTP treatment, did not lead to cell loss in the SN or to loss of dopaminergic terminals. These data demonstrate that overexpression of Pgc-1α results in dopamine depletion associated with lower levels of Pitx3 and enhances susceptibility to ...
Proton reaction cross-section measurements on various stable and neutron-rich nuclei ( He, Li, Be, F, Ne, Na and Mg) were performed via the attenuation met... AD Vismes,P Roussel-Chomaz,W Mittig,... - 《Retour Au Numéro》 被引量: 117发表: 2002年 ...
children with HbSS may express symptoms of illness at a lower parasite biomass and with less inflammation than children with HbAA, or that SCA-related mechanisms, still not fully characterized, may lead to attenuation of parasite sequestration and sequestration-driven inflammation in children with SCA...
On the basis of these results in all the following experiments (2–7), we used 50 pre-exposures and 2 conditioning trials. Experiment 2: Effects of Amphetamine (1 mg/kg) on LI in Sham and OVX Rats Figure 2 presents the mean log times to complete licks 76–100 (after tone onset) of...
Changes in TCA cycle enzymes or respiratory activity are possible mechanisms of aerobic glycolysis that contributes to tumor progression. To clarify whether the decrease of succinate dehydrogenase B (SDHB) alters energy metabolism, induces the Warburg effect and results in tumor malignancy, SDHB expressio...