However, all methods of decellularization invariably disrupt the ECM to some degree. Decellularization of tissues and organs for the production of ECM bioscaffolds requires a balance between maintaining native ECM structure and the removal of cellular materials such as DNA, mitochondria, membrane ...
Decellularization of tissues and organs Biomaterials, 27 (19) (2006), pp. 3675-3683 View PDFView articleView in ScopusGoogle Scholar [53] P.M. Crapo, T.W. Gilbert, S.F. Badylak An overview of tissue and whole organ decellularization processes Biomaterials, 32 (12) (2011), pp. 3233...
A new field of investigation which aims to design tissues and organs similar to their native origin has been developed recently, named as regenerative medicine (tissue engineering and bio-engineering). Uterus is the main organ for regeneration and contri
TRANSPLANTATION of organs, tissues, etc.TISSUE engineeringOne of the main problems of the decellularization technique is the subjectivity of the final evaluation of its efficacy in individual organs. This problem can result in restricted cell repopulation reproducibility and worse responses to transplant...
properties of ECM are important in the fields of tissue engineering and regenerative medicine, which often aim to replicate the composition and structure of the ECM. By using synthetic or natural materials, three-dimensional scaffolds can be fabricated to repair or restore damaged organs and tissues...
Tissue-engineered substitutes, with properties similar to the native tissue, might represent a solution for the functional reconstruction of bile ducts. In particular, decellularized tissues and organs represent a suitable option for tissue engineering when specific scaffolds are needed. However, the ...
The aim of tissue decellularization is to remove tissue antigenicity, avoiding the use of glutaraldehyde and improve valve integration with low inflammation and host cell recolonization. In this preliminary study, we investigated the efficacy of a NaOH-based process for decellularization and ...
The product is a 3D structure of the ECM that can serve as a template to promote the restoration of tissues after implantation or to create bioengineered organs [40]. The acellular scaffold provides architectural support and most importantly, has functions in homeostasis, regeneration, tissue, and...
WO1988003785A11988-06-02CHIMERIC NEOMORPHOGENESIS OF ORGANS BY CONTROLLED CELLULAR IMPLANTATION USING ARTIFICIAL MATRICES Other References: International Search Report, PCT/US00/33782, issued Apr. 5, 2001. Schmidt, C.E., “Acellular Vascular Tissues: Natural Biomaterials for Tissue Repair and Tissue ...
Schmidt, “Acellular Vascular Tissues: Natural Biomaterials for Tissue Repair and Tissue Engineering,” Biomaterials, vol. 21, 2000, pp 2215-2231. ;, vol. 21, 2000, pp 2215-2231. Walton et al., “Tissue Engineering of Biomaterials for Composite Reconstruction: An Experimental Model,” Annals ...