Pyruvate undergoes oxidative decarboxylation in the mitochondrial matrix catalyzed by the mtPDH complex (mtPDC) to yield acetyl-CoA, CO2, and NADH; acetyl-CoA is incorporated into the TCA cycle [2, 26, 53]. The fact that this reaction is irreversible, links glycolysis and the TCA cycle, and...
Where do decarboxylation reactions happen in carbohydrate metabolism? Decarboxylation: Decarboxylation takes place in the cytoplasm of both - prokaryotes and eucaryotes under anaerobic conditions. This is the reaction that produces CO2 in the fermentation process used for the...
In presence of 0.5 mM AMP, the decarboxylation reaction was inhibited up to 50% of the control while even in presence of 5 mM AMP, the carboxylation reaction was unaffected (Fig. 3). Lombricine phosphate, one of the naturally occurring phosphagens in Tubifex , activates the PEPCK-catalyzed...