The conclusion is that the enzymatic environment per se could accelerate the decarboxylation reaction so that little additional catalysis is required. The Dunathan hypothesis, according to which the bond between the C2α atom and the departing carboxyl carbon atom should be perpendicular to the ...
Guoet al.have found that the degradation rate of SMX increases with increasing pH value. SMX has twopKavalues, of 1.6 and 5.7, resulting in protonated, non-protonated and deprotonated forms at different pH values. The amino groups are possible reaction centres that are most susceptible to O3el...