The initiation of apoptosis is closely related to ROS activity (Fig.3). Mitochondria serve as the primary intracellular source of ROS and emanate from electron leakage within the respiratory ETC. The repercussions of these mitochondrial ROS include potential damage to neighboring structures, including m...
The initiation of apoptosis is closely related to ROS activity (Fig.3). Mitochondria serve as the primary intracellular source of ROS and emanate from electron leakage within the respiratory ETC. The repercussions of these mitochondrial ROS include potential damage to neighboring structures, including m...
Through TCGA database analysis and immunohistochemical staining, ACSL4 is down-regulated in lung adenocarcinoma. When ACSL4 is knocked down in vitro, the survival rate and invasiveness of lung cancer cells are enhanced, on the contrary, overexpression would promote ferroptosis of lung cancer cells [...
Glutathione system activator Other than providing raw materials for the GSH system, another antioxidant strategy that activates the glutathione system is often achieved through medicinal therapy. In this section, we will describe their effects and mechanisms in detail by the source of the drugs. Natura...
Other than providing raw materials for the GSH system, another antioxidant strategy that activates the glutathione system is often achieved through medicinal therapy. In this section, we will describe their effects and mechanisms in detail by the source of the drugs. ...
In advanced atherosclerosis (AS), defective function-induced cell death leads to the formation of the characteristic necrotic core and vulnerable plaque. The forms and mechanisms of cell death in AS have recently been elucidated. Among them, ferroptosis,
The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression. Within the TME, angiogenesis is predominan