1g,h). We term mitotic lethality in the first attempted cell division ‘immediate mitotic death’ and cell death following at least one cell division ‘delayed lethality’. DSB repair impacts how cells die following genome damage Correlation between cell death mode and cell cycle phase at IR ...
Delayed neuronal apoptosisL-type voltage-gated calcium channels (L-VGCCs) are thought to be involved in epileptogenesis and acute excitotoxicity. However, little is known about the role of L-VGCCs in neuroinflammation or delayed neuronal death following excitotoxic insult. We examined the effects ...
MOMP results in the release of proapoptotic intermembrane space (IMS) proteins that promote the formation of a molecular complex called the apoptosome, leading to caspase-9 engagement and caspase-3 and -7 activation.2 The extrinsic pathway can be activated by ligand binding of a subset of ...
Park J-S, Kim D-H, Yoon S-Y. Regulation of amyloid precursor protein processing by its KFERQ motif. BMB Rep. 2016;49:337. Article CAS PubMed PubMed Central Google Scholar Wild EJ, Tabrizi SJ. Targets for future clinical trials in Huntington's disease: what's in the pipeline? Mov ...
Kim, C. Park Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1 Leuk. Lymphoma, 53 (2012), pp. 1586-1591 CrossrefView in ScopusGoogle Scholar 128 S.-M. Kim, D.Y. Hur...
(TNF) family of cytokines to their cognate cell surface death domain–containing receptors (members of the TNF superfamily of cytokine receptors), for example, TNFR1, CD95-Fas, and TNF-related apoptosis-inducing ligand (TRAIL) receptor (TRAIL-R; for review, see Park et al,44 Haase et al,...
Death Valley National Park, California Situated in the southeast part of California, Death Valley covers an area of more than 3.3 million acres, even larger than the famous Yellowstone National Park. Death Valley is a land of extremes. It is one of the hottest places on the surface of the ...
Situated in the southeast part of California, Death Valley covers an area of more than 3.3 million acres, even larger than the famous Yellowstone National Park. Death Valley is a land of extremes. It is one of the hottest places on the surface of the earth. The highest ground temperature ...
Abstract Cancer cells are disordered by nature and thus featured by higher internal redox level than healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain threshold, rendering therapeutic strategies relying on redox control a possible cancer management solution. Yet, va...
RIPK3 is involved in the release of inflammatory factors; however, the mechanisms through which RIPK3 promotes inflammatory responses warrant further investigation. Open questions Can RIPK3 be used as a drug target for the treatment of cancer?