it is not clear whether THF1 is also involved in FR-preconditioned cell death. We adopted a genetic approach to answer this question using thethf1null mutant.
A patent has been filed with data generated in this manuscript, where TH is listed as one of the inventors. The patent is fully owned by a non-profit public foundation, the Helleday Foundation for medical research (THF), and TH and UWB are members of THF board. Oxcia AB has license to...
Methyl groups required for DNA synthesis & methylation ultimately come from folic acid (THF, TetraHydroFolate) in the diet, which is converted to the methyl donor S−AdenosylMethionine (SAM). The enzyme DNA cytosine-5-MethylTransferase 1 (DNMT1) catalyzes the methylation of DNA by SAM. During...
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International Journal of Molecular Sciences Review Cell Death in Chondrocytes, Osteoblasts, and Osteocytes Toshihisa Komori Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan; komorit@nagasaki-u.ac.jp; Tel.:...
religions Article Losing Touch: A Theology of Death for Michael Haneke's Amour Taylor Worley Department of Philosophy, Trinity International University, 2065 Half Day Road, Village of Bannockburn, Deerfield, IL 60015, USA; tbworley@tiu.edu; Tel.: +1-847-317-4061 Academic Editor: Joseph Kick...
International Journal of Molecular Sciences Review Tocotrienols Modulate a Life or Death Decision in Cancers Shiau-Ying Tham 1, Hwei-San Loh 1,2,* , Chun-Wai Mai 3,4 and Ju-Yen Fu 5,* 1 School of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia Campus, ...
materials Article Hinokitiol-Loaded Mesoporous Calcium Silicate Nanoparticles Induce Apoptotic Cell Death through Regulation of the Function of MDR1 in Lung Adenocarcinoma Cells Yu-Fang Shen 1, Chia-Che Ho 1,2,3, Ming-You Shie 1, Kan Wang 2,3 and Hsin-Yuan Fang 1,4,5,* 1 3D Printing ...
International Journal of Molecular Sciences Article Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells Jui-Hung Yen 1,†, Pei-Shan Wu 2,†, Shu-Fen Chen...
International Journal of Molecular Sciences Article T315 Decreases Acute Myeloid Leukemia Cell Viability through a Combination of Apoptosis Induction and Autophagic Cell Death Chang-Fang Chiu 1,2,3, Jing-Ru Weng 4,5, Appaso Jadhav 6, Chia-Yung Wu 5, Aaron M. Sargeant 7 and Li-Yuan Bai 1,...