Heart disease: Preventing the death of heart muscle cells A protein known as Rubicon, which inhibits the routine degradation of cell components in a process called autophagy, has been identified as a possible target for drugs to prevent the death of heart muscle cells. Autophagy is required for...
The heart fails if it cannot supply sufficient blood flow to meet the body's needs. This functional deficit can be caused by the death of cardiac muscle cells due to an insufficient blood supply to the heart itself, or to defects in the inner workings...
Eur Heart J. 2014;35:1515–25. Article PubMed PubMed Central Google Scholar Durham AL, Speer MY, Scatena M, Giachelli CM, Shanahan CM. Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness. Cardiovasc Res. 2018;114:590–600. Article ...
The heart fails if it cannot supply sufficient blood flow to meet the body's needs. This functional deficit can be caused by the death of cardiac muscle cells due to an insufficient blood supply to the heart itself, or to defects in the inner workings of the muscle cells or in the heart...
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She was identified by a partial thumb print and by the pacemaker implanted six years earlier to support her damaged heart muscle. Eva’s immediate cause of death was determined to be heart failure caused by inhaling crack cocaine. Hans Kristian was charged with preventing Eva’s lawful burial....
Nakamura M,Tanaka M,Abe S,et al.Sudden pressure elevation can trigger acute muscle cell death of the heart and aorta.Atherosclerosis. 1999Nakamura M, Tanaka M, Abe S, Fujiwara H. 1999. Sudden pressure elevation can trigger acute muscle cell death of the heart and aorta. Atherosclerosis 146:...
However, it is uncertain whether such dysfunction is due to a combination of Trib1 knockout in other tissues such as the liver and muscle. Therefore, we overexpressed Trib1 in 3T3-L1 preadipocytes and induced the differentiation and maturation of these cells (Supplemental Fig. 7). Oil Red O...
Ferroptosis represents a form of programmed cell death that is propelled by iron-dependent lipid peroxidation, thereby being distinguished by the prominent features of iron accumulation and lipid peroxidation. Ferroptosis has been implicated in numerous
KEYTRUDA is an anti-programmed death receptor-1 (PD-1) therapy that works by increasing the ability of the body’s immune system to help detect and fight tumor cells. KEYTRUDA is a humanized monoclonal antibody ...