was taken with the Hubble Space Telescope. This image illustrates the life cycle of stars. In the bottom half of the image, we see clouds of dust and gas, where it is likely that star formation will take place in the near future. Near the center, there is a cluster ...
Programmed cell death-1 (PD-1; CD279) is acell surface receptorthat is expressed in both innate and adaptiveimmune cells. The role of PD-1 in adaptive immune cells, specifically in CD8+T cells, has been thoroughly investigated but its significance in other immune cells is yet to be we...
Since the elements synthesized in the explosion of massive stars are the building blocks for much of the visible Universe, it is important to understand the life cycle of these massive stars. IAU Symposium 279 brings together international leaders who study CCSNe and GRBs to discuss their ...
Triggered release and targeted drug delivery of potent anti-cancer agents using hyperthermia-mediated focused-ultrasound (FUS) is gaining momentum in the clinical setting. In early phase studies, tissue biopsy samples may be harvested to assess drug deli
Synergistic interaction of nitric oxide (NO) and reactive oxygen species (ROS) is essential to initiate cell death mechanisms in plants. Though autophagy is salient in either restricting or promoting hypersensitivity response (HR)-related cell death, the
Learn the definition of Death and browse a collection of 333 enlightening community discussions around the topic.
- 《Journal of the American Society of Echocardiography》 被引量: 61发表: 2012年 Chlamydophila pneumoniae derived from inclusions late in the infectious cycle induce aponecrosis in human aortic endothelial cells Atherosclerosis is still the leading cause of death in the western world. Besides known...
2. Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins.Science.2022;375:1254–61. 3. Kruiswijk F, Labuschagne CF, Vousden KH. p53 in survival, death and metabolic health: a lifeguard with a licence to kill.Nat Rev Mol Cell Biol...
抑制胱氨酸谷氨酸反转运蛋白会导致细胞CC和GSH的消耗,进而破坏氧化还原稳态,最终导致铁死亡,同时,在CC缺失所致的铁死亡中,三羧酸循环(tricarboxylic acid cycle,TCA循环)和ETC活性都是脂质ROS生成的必要条件。然而,COX7A1、自噬、线粒体和铁死亡之间的具体关系尚不清楚。
More clues for this role of ferroptosis can be derived from recent researches of the tumor suppressor P53 (TP53). The acetylation-defective mutant TP533KR lost the ability to induce cell senescence, apoptosis, and cell-cycle arrest, which were the main functions of TP53 in tumor suppression. ...