A Personal View on p53: Henning Walczak (video) The main theme of Dr. Henning Walczak's research focuses on death receptor proteins. Walczak's team has been interested in how these important regulators of cell death synergize with p53. Indeed he discusses, in Montalcino in Tuscany, Italy, th...
Annexin V and propidium iodide (PI) labeling of cells is a technique used to identify cell death, and distinguish between its different pathways: apoptosis, or programmed cell death, and necrosis. Cells undergo distinct morphological changes depending on the pathway. By identifying the specific condi...
Cell death in cell culture frame by frame: Spontaneous cell demise of a 3T3 fibroblasttimelapse videomicroscopy3T3 fibroblastspontaneous cell deathphase-contrastKeywords:timelapse videomicroscopy;3T3 fibroblast;spontaneous cell death;phase-contrastdoi:10.1111/j.1582-4934.2003.tb00219.x...
Cell Death & Disease |李继喜团队发现转录因子Sp1通过调控GSDME表达影响细胞焦亡水平 细胞焦亡是机体通过免疫反应抑制肿瘤发生和发展的重要途径,而异常的细胞焦亡则会制约多种肿瘤疗法的实施。一些肿瘤细胞通过抑制焦亡相关基因表达或激活负调节通路,使其抗化疗药物能力增强[1];但在药物化疗和CAR-T疗法中,肿瘤免疫造成的...
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Double-strand breaks (DSBs) can initiate mitotic catastrophe, a complex oncosuppressive phenomenon characterized by cell death during or after cell division. Here we unveil how cell cycle-regulated DSB repair guides disparate cell death outcomes through
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Cell death occurs in all eukaryotes, but it is still not known whether some core steps of the cell death process are conserved. We investigated this using the protist Dictyostelium. The dissection of events in Dictyostelium vacuolar developmental cell de
Cell Injury & Cell Death Grace Denton & Stephanie Tristram G.E.Denton@warwick.ac.uk S.C.Tristram@warwick.ac.uk What are some of the causes of cell injury and cell death? Loads of stuff can cause ‘cell injury’ – from a car crash to minute internal abnormalities such as a genetic mu...
Kira uses the Orb of Time to travel into the past after Dukat claims that her mother was once his lover during the Occupation. In Quark's, Jadzia Dax unsuccessfully tries to convince Worf to let her throw a party with the crew of the USS Saratoga in thei