Pepirium of IGN saying that Death Note's "heavy serialized nature" is what "makes the show so engaging and discussion worthy."[75] Pepirium, saying that translating Death Note is "no small task," said that Stephen Hedley created a dub with "nothing clunky." Pepirium added that Karl ...
Conclusions Using a DUB expression library, we found that OTUD1 regulates the stability of the MCL1 protein. OTUD1 interacts with and promotes the deubiquitination of MCL1 in an enzymatic-activity dependent manner. Through regulating MCL1 stability, OTUD1 regulates the induction of cell death by ...
As a deubiquitination enzyme (DUB), CYLD could remove the K63-linked polyubiquitin chains from substrates and affect various cellular functions. Decreased CYLD expression is involved in diverse kinds of tumor, CYLD has been regarded as a tumor suppressor gene [70]. CYLD has been reported to inte...
Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J Cell Sci. 2018;131:jcs212753. Yang CS, Sinenko SA, Thomenius MJ, Robeson AC, Freel CD, Horn SR, et al. The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Cell ...
Scrub-a-dub. etonalife Posted 28 July 2008 at 10:44 pm There is a boom going on in deep off-shore oil drilling. Many rig companies are in the process of building more of these rigs to be shipped to foreign coasts (NOTE: this has nothing to do with the shallow water politically ...
The thing is about T-Dub, he cannot erase. That's what he really wants. He wants to erase the things that happened." Slowly, year by year, Tiger's name will not be spoken in the same way and with the same frequency. Without a new passion, Tiger just might sit down the...
leading to enhanced RIPK1 K63-linked ubiquitination and survival signal of Adult T-cell leukemia/lymphoma cells [72]. Moreover, cancer-related mutations alter CYLD structure and which disturb its binding capacity to K63 ubiquitin molecule. The absence of CYLD DUB activity enhances cancer-promoting...
(DUB) are also involved in the regulation of ERα in breast cancer. A previous study demonstrated that USP7 was a potential deubiquitylase of ERα and promoted breast cancer progression [23]. However, to explore exact mechanisms underlying ERα dysfunction is still in need of further ...
Of note, only a handful of deubiquitylases have so far been associated with the endocytic pathway, which are recurrently exemplified by AMSH, USP8, and USP2, hence suggesting promiscuous DUB activity on endo-lysosomes. Interestingly, deubiquitylases can lead to either positive or negative ...
We present key regulatory elements of JOSD1 within the Hippo pathway, shedding light on the interplay between the DUB family and the Hippo pathway. The connection between Hippo signaling and colon cancer has been established for decades [34]. Targeting YAP function shows promise in colon cancer ...