Ferroptosis represents a form of programmed cell death that is propelled by iron-dependent lipid peroxidation, thereby being distinguished by the prominent features of iron accumulation and lipid peroxidation. Ferroptosis has been implicated in numerous
and although autosis-mediated death cannot be completely rescued after pharmacological inhibition of autophagy, we include a description of autosis as a form ADCD in this paper. Autosis has recently been identified and is characterized by an increase in the number of autophagic vacuoles...
To develop a great response, CAR-T cells must enter tumor cells, detect their relevant antigen, and fulfill their cytotoxic role in the TME, and then develop and persist as memory T cells that provide long-term immunity [144]. The poor results of CAR T cells in clinical studies of solid...
Antigen- presenting cells (APCs) recognize and phagocytize dead cell antigens and present them to T cells, promoting the formation of antigen-specific cytotoxic T lymphocytes (CTLs) and activating the adaptive immune response to recognize and clear tumour antigens, resulting in long- term anti...
An aid to data monitoring in long-term clinical trials. Control Clin Trials.1982;3:311-323.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7160189&dopt=AbstractGoogle Scholar 38. Lan KK, Wittes J. ...
Recently, chimeric transcripts have been found to be associated with the pathogenesis and poor prognosis of malignant tumors. Through our preliminary experiment, a novel chimeric transcript called chimeric transcript RRM2-c2orf48 was detected in C666-1,
And just like that, the future he and his wife had imagined evaporated.When Breath Becomes Airchronicles Kalanithi’s transformation from a naïve medical student “possessed,” as he wrote, “by the question of what, given that all organisms die, makes a virtuous and meaningful life” into...
lifetime risk of those who have puberty at age 16. Women who have menopause at age 42 (ten years earlier than the median 52) have 35% less breast cancer. Women who have a full-term pregnancy by age 18 have nearly a third the risk of breast cancer of women who never experience ...
However, this term is unclear and it sometimes may confuse the reader into thinking that the cells of interest are undergoing cell death without providing direct evidence of such event. We found that both the SW620 and SKOV3 cell lines respond to cisplatin and topotecan treatment with a ...
N. Long-term outcomes following CAR T cell therapy: what we know so far. Nat. Rev. Clin. Oncol. 20, 359–371 (2023). Article CAS PubMed PubMed Central Google Scholar Larson, R. C. & Maus, M. V. Recent advances and discoveries in the mechanisms and functions of CAR T cells. ...