experiment. 1.) Each person must return to their room by 10 PM. 2.) At the end of 7 days or when there are only two surviving members left alive the experiment will end. The next day a person is found shot to death. Now, what looked like a dream job will turn into a nightmare...
Thalidomide, and the structurally related iMiD analogs lenalidomide and pomalidomide, have been shown to har- ness ubiquitin machinery through recruitment of neo- substrates to the ubiquitin ligase complex CRL4CRBN (CUL4-RBX1-DDB1-CRBN) for ubiquitination and sub- sequent proteasomal degradation. The...
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