For those unaware, the phrase “death by snu-snu” comes from the cartoonFuturama. The main characters are taken hostage by gigantic, burly women called the Amazonians who live on the planet they’ve visited. They are soon sentenced to death by the very deadly “snu-snu”, a term left ...
Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway. Cell Death Dis. 2018, 9, 15. [CrossRef] [PubMed] 42. Liu, H.; Qian, C.; Shen, Z. Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway...
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However, while enhancing autophagy could provide neuroprotection by promoting aggregate degradation, on the other hand its activation can also be detrimental to neurons [19,20]. Therefore, while autophagy activation can promote survival when the accumulation of toxic cellular components is the primary ...
The cell death mechanisms elicited by tocotrienols, particularly apoptosis and autophagy, are highlighted. The influences of several cell survival signaling pathways in shaping cancer cell death, particularly NF-κB, PI3K/Akt, MAPK, and Wnt, are also reviewed. This review may stimulate further ...