Human blood platelets were found to carry the complete pathway of de novo purine nucleotide synthesis. The rate of purine synthesis was gauged by the rate of incorporation of precursor (14C)formate into purines. The effect on formate incorporation of several compounds known to inhibit purine ...
百度试题 结果1 题目Lesch^Nyhan 综合征 4・ de novo synthesis of purine nucleotide相关知识点: 试题来源: 解析 由于基因缺陷而导致HGPRT完全缺失的患儿。反馈 收藏
Thekey differencebetween de novo and salvage pathway is thatde novo synthesis ofpurinenucleotides refers to the process that utilizes small molecules such as phosphoribose, amino acids, CO2etc. as raw materials to produce purine nucleotides, while salvage pathway of purine synthesis refers to the pr...
百度试题 结果1 题目denovosynthesispurinenucleotide2.核苷酸的补救合成 相关知识点: 试题来源: 解析 以酶的竞争性抑制作用的原理,说明用别嘌呤醇治疗痛风症的机理。反馈 收藏
These findings indicate that the full development of reproductive function in the male requires HPRT as well as purinesynthesis.doi:10.1203/00006450-198507000-00023Allsop, JenniferWatts, Richard W EPediatric ResearchAllsop J. & Watts R.W. (1986) Purine de novo synthesis and sal- vage during ...
Lung cancer tissues used de novo–synthesized Ser and Gly far more than exogenous supplies for purine synthesis, which can be attributed to activation of de novo Ser synthesis, dynamic compartmentation of de novo Ser synthesis products in the cytoplasm, efficient access of these products to the ...
So, the de novo synthesis of purine and pyrimidine is strictly regulated at multiple levels in cells. Here, we will introduce the regulatory mechanisms of de novo nucleotide biosynthetic pathway from the following three aspects: regulation of precursors; regulation of the key enzymes at transcription...
Fig. 1: The serine synthesis pathway (SSP) and downstream anabolic pathways. ASerine synthesis pathway. Serine is shown to be both imported from the extracellular space by amino acid exchangers and also synthesised de novo from glucose. The first rate-limiting enzyme, PHGDH, oxidises 3-phosphogl...
Procedures for assaying the rate of purine de novo synthesis in cultured fibroblast cells have been compared. These were (i) the incorporation of [ 14C]glycine or [ 14C]formate in α-N- formylglycinamide ribonucleotide (an intermediate in the purine synthetic pathway) and (ii) the incorporation...
Anew; often applied to particular biochemical pathways in which metabolites are newly biosynthesized (for example, de novo purine biosynthesis). [L.] Farlex Partner Medical Dictionary © Farlex 2012 (dē nō′vō, dā, nō′wō) 1.Over again from the beginning; anew. ...