Our understanding of whether the presynaptic proteins undergo de novo synthesis during long-term memory formation is limited. In this study, we investigated the involvement of syntaxin-1, a presynaptic exocytotic protein, and dynamin-1, an endocytotic protein, i...
protein synthesisproteostasisOXPHOS complexesMitochondria are multifunctional organelles with their own genome and protein synthesis machinery. The 13 proteins encoded by mitochondrial DNA (mtDNA) are core subunits of the oxidative phosphorylation (OXPHOS) system producing the majority of cellular ATP. Yet ...
Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA. Loh HH, Wei LN (2006) Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA. J... Tsai,N.-...
Low-energy laser irradiation enhances de novo protein synthesis via its effects on translation-regulatory proteins in skeletal muscle myoblasts - ScienceDi... Low-energy laser irradiation enhances de novo protein synthesis via its effects on translation-regulatory proteins in skeletal muscle myoblasts - ...
Fig. 1: Surface-centric design of de novo site-specific protein binders. a, Schematic of fingerprint generation. Protein binding sites are spatially embedded as vector fingerprints. Protein surfaces are decomposed into overlapping radial patches, and a neural network trained on native interacting prote...
Vinculin, VASP, and profilin are coordinately regulated during actin remodeling in epithelial cells, which requires de novo protein synthesis and protein k... Quinlan MP.Vinculin, VASP, and profilin are coordinately regulated during actin remodeling in epithelial cells, which requires de novo protein ...
It is the state in which the protein is extracted from living material, and from which experimental studies start (unless there is synthesis of a protein purely chemically, which is now possible as An early recipe for de novo prediction methods For computer simulation scientists, Anfinsen's view...
Finding new molecules with a desired biological activity is an extremely difficult task. In this context, artificial intelligence and generative models have been used for molecular de novo design and compound optimization. Herein, we report a generative
both the semantic and grammatical meaning of a particular word. Intuitively, it appears that this ability may be helpful in capturing 3D features of a protein binding pocket. For example, a model may consider a certain residue simultaneously in two aspects: forming the pocket and interacting direc...
we present ade novotranscriptome analysis of an elite cultivar ofZ. bungeanumusing Illumina sequencing; we then developed simple sequence repeat markers for identification ofZanthoxylum. In total, we predicted 45,057 unigenes and 22,212 protein coding sequences, approximately 90% of which showed sign...