Wikipedia (2007) De novo protein structure prediction, http://en.wikipedia.org/wiki/De_novo_protein_structure_prediction, July.Hung L-H, Ngan S-C, Samudrala R. De novo protein structure pre- diction. In: Xu Y, Xu D, Liang J, editors. Computational methods for protein structure prediction...
在骨架采样中,首先将局部序列中的可能结构作为局部结构的子集,构建离散优化问题;然后使用准牛顿最小化(quasi-Newton minimization)等连续优化方法调整蛋白质结构(此时主要调整的是静电相互作用和氢键对蛋白质结构的影响)。 蛋白质结构预测(Protein-structure prediction) 蛋白质的结构预测:指在不知道相关进化蛋白结构信息的...
Proteins: Structure, Function, and BioinformaticsFujitsuka,Y., Chikenji,G. and Takada,S. (2005) SimFold energy function for de novo protein structure prediction: consensus with Rosetta. Proteins, 62, 381-398.Fujitsuka Y, Chikenji G, Takada S (2006) SimFold energy function for de novo ...
Building a better fragment library for de novo protein structure prediction.doi:10.1371/journal.pone.0123998Fragment-based approaches are the current standard for de novo protein structure prediction. These approaches rely on accurate and reliable fragment libraries to generate good structural models. In ...
protein modelling, probably due to the complexity of protein backbone geometry and sequence–structure relationships. Here we show that by fine-tuning the RoseTTAFold structure prediction network on protein structure denoising tasks, we obtain a generative model of protein backbones that achieves ...
we address the issue of the utility of protein structure prediction techniques to thede novoprediction of intrinsically disordered protein ensembles and protein backbone dynamics by developing FRAGFOLD-IDP. Using only sequence information we bypass the limitations of computational simulation techniques imposed...
De novo design is an attractive approach for constructing designed peptides with predetermined structures and functions. Creative Peptides provides de novo design related services for peptides engineering, including peptides structure prediction, peptides folding and interactions, thermodynamics information, ...
1、#流程大放送#微生物基因组Denovo测序分析知因无限一 介绍微生物基因组De novo测序分析也叫微生物基因组从头测序分析,指不依赖于任何参考序列信息就可对某个微生物进行分析的测序分析技术,用生物信息学的方法进行序列拼接获得该物种的基因组序列图谱,然后进行注释等后续一系列的分析。微生物Denovo基因组测序及分析...
Structure-based de novo prediction of zinc-binding sites in proteins of unknown function.Motivation: Zinc-binding proteins are the most abundant metallo-proteins in Protein Data Bank (PDB). Accurate prediction of zinc-binding sites in proteins of unknown function may provide important clues for the...
A new de novo protein structure prediction method for transmembrane proteins (FILM3) is described that is able to accurately predict the structures of larg... T Nugent,David T.Jones - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 250发表: 2012年...