是什么意思 释义 从头合成,全程合成; 英英释义 De novo synthesis De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to their being recycled after partial degradation. For example, nucleotides are not needed in the diet as...
De novo fatty acid synthesis at the mitotic exit is required to complete cellular division 来自 万方 喜欢 0 阅读量: 27 作者: Scaglia, Natalia,Tyekucheva, Svitlana,Zadra, Giorgia,Photopoulos, Cornelia,Loda, Massimo 摘要: Although the regulation of the cell cycle has been extensively studied, ...
These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes inde novofatty-acid synthesis and related pathways.关键词: lipid metabolism fatty-acid synthase acyl-CoA synthetase ...
Notably, pharmacologic inhibition or T cell–specific deletion of ACC1 not only blocks de novo fatty acid synthesis but also interferes with the metabolic flux of glucose-derived carbon via glycolysis and the tricarboxylic acid cycle. In vivo, treatment with the ACC-specific inhibitor soraphen A ...
B-gal, β-galactosidase; Elovl, fatty acid elongase; FA, fatty acid; INS, rat insulinoma; SCD, stearoyl-CoA desaturase. DISCUSSION The role of FA elongases in determining end products of de novo FA synthesis from glucose has been largely speculative. Although substrate specificities of Elovl-5...
Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming...
In pigs, adipose tissue is one of the principal organs involved in the regulation of lipid metabolism. It is particularly involved in the overall fatty acid synthesis with consequences in other lipid-target organs such as muscles and the liver. With this
Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-kappa B) signaling in cancer cells 喜欢 0 阅读量: 35 作者: Senga,Shogo,Kobayashi,Narumi,Kawaguchi,Koichiro,Ando,Akira,Fujii,Hiroshi ...
Fatty acids derived from de novo lipogenesis are preferentially incorporated into storage lipids such as TAG and secreted as very low density lipoprotein rather than mitochondrial oxidation (19, 42). Additionally, an intermediate in de novo fatty acid synthesis, malonyl-CoA, allosterically inhibits ...