GDP-fucose is synthesised via two pathways: de novo and salvage. The first uses GDP-mannose as a substrate, and the second uses free fucose. To date, these pathways have been considered to work separately and not to have an influence on each other. We report ...
The relative contribution of the de novo or salvage pathways may vary between cell types. It has been suggested that highly proliferative cancer cells may be more dependent on the de novo pathway, whereas slow growing, resting cells and fully differentiated cells opt for the less energy demanding...
The relative contribution of de-novo and salvage synthesis to tissue pyrimidine nucleotide pools is an important parameter in the rational design of anti-pyrimidine therapies, but has not been measured in vivo. We have measured the contribution of de-novo synthesis to the total acid-soluble uracil...
De novo synthesis means the microbial fermentation of complex substrates (sugars and related substrates) and formation of desirable molecules. Microbial-derived aroma compounds produced by de novo synthesis included terpenes, esters, aldehydes, and alcohols. Terpenes are mainly produced by biotransformation...
De novo pyrimidine biosynthesis is achieved by cytosolic carbamoyl-phosphate synthetase II, aspartate transcarbamylase and dihydroorotase (CAD) and uridine 5′-monophosphate synthase (UMPS), and mitochondrial dihydroorotate dehydrogenase (DHODH). However, how these enzymes are orchestrated remains enigmatical...
Factors controlling relative flux rates of the de novo and salvage pathways of purine nucleotide biosynthesis during animal cell growth are not fully understood. To examine the relative role of each pathway for cell growth, three cell lines including CHO K1 (a wild-type Chinese hamster ovary fibro...
degradation. For example, de novo synthesis of nucleotides is an alternative to the salvage pathway...
de novo synthesis(从头合成) :应该是从简单的碳氢化合物开始合成total synthesis (全合成):应该是从廉价易得的原料开始把,或从较容易得到目标化合物的原料开始,所需反应步骤应简单De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids,as opposed ...
de novo synthesis(从头合成) :应该是从简单的碳氢化合物开始合成 total synthesis （全合成）：应该是从廉价易得的原料开始把，或从较容易得到目标化合物的原料开始，所需反应步骤应简单 De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino ...
In this context, also the de novo and salvage synthesis of purine and pyrimidine nucleotides, the key precursors of DNA and RNA, have been reported as essential for mycobacterial survival both in vitro and in vivo9, and therefore represents a source of promising targets for the development of ...