The eligible 454 adults were categorized as the de-escalation (231 patients, 50.9%), no-switch (177, 39.0%), and escalation (46, 10.1%) groups. Patients with de-escalation therapy were more often female, had less critical illness and fatal comorbidity, and had a higher survival rate than...
After filtering likely contaminants, 33/276 (12%) returned relevant positive results, of which 20/33 (61%) had antimicrobials changed from empiric therapy as a result with 6/33 (18%) prompting de-escalation. Positive blood and CSF tended to have greater impact than urine or sputum cultures....
Conclusions: In a broad population of critically ill adults, 13% of respiratory and 15% of blood cultures ultimately growing ceftriaxone resistant GNRs have not demonstrated growth at 48 hours. De-escalation from agents targeting Pseudomonas aeruginosa and extended-spectrum 尾-lactamases may not ...
the approach to assignment of spectrum scores to antimi- crobials, application of the scores to electronic medical records data to generate spectrum scores for antimicro- bial regimens; refinement and validation of the method to measure antimicrobial de-escalation in patients with Healthcare Associated...
A phase I dose-escalation study determined the biologically effective dose for guadecitabine to be 60 mg/m2 for five consecutive days in 28-day cycles. This is similar to the dosage schedule that has been approved for decitabine [56,57]. A multicenter, open-label, phase II dose expansion ...
This paper focuses on the deprescriptive flow chart application during three months of ward activities, in particular evaluating the applicability to hospital clinical practice of the PPIs prescription/deprescription flow chart and its adherence abided by hospital prescribers, with the presence of a cli...
Safety and efficacy of CD7-CAR-T cell in patients with relapsed/refractory T-lymphoblastic leukemia/lymphoma: Phase I dose-escalation/dose-expansion study. 标题:CD7-CAR-T细胞在复发/难治性T淋巴细胞白血病/淋巴瘤患者中的安全性和有效性:I期...
the approach to assignment of spectrum scores to antimi- crobials, application of the scores to electronic medical records data to generate spectrum scores for antimicro- bial regimens; refinement and validation of the method to measure antimicrobial de-escalation in patients with ...
Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Group B study 9621. J Clin Oncol, 22 (2004), pp. ...
Since the anti-CD123 CAR T cell-treated mice did not eliminate the AML cells entirely, we sought a combination partner that would increase in vivo efficacy by upregulating the expression of CD123 on AML cells. Based on our knowledge of currently approved therapeutic agents for the treatment of...