Both inside and outside the services a view criticising the ill effects of prolonged stay within the large institutions emerged with increasing force during the 1950s [29]. Sociologists and professionals argued that the 'total institution' maintained or created dependency, passivity, exclusion and di...
185 of NM_001396.3. This insertion altered the translational frame, generated a premature translation termination codon (TGAG) at the E396 (GAG) position, and produced a truncated protein of 395 amino acids (DYRK1A-E396ter) (Fig.1b). To gain...
Coffin–Siris syndrome (CSS) is a multiple malformation syndrome characterized by intellectual disability associated with coarse facial features, hirsutism, sparse scalp hair, and hypoplastic or absent fifth fingernails or toenails. CSS represents a smal
disability13,14. As an example, a heterozygous likely pathogenic frameshift DNM was observed in the LoF-intolerant geneGREB1L(pLI = 1) of Proband_076. HomozygousGreb1lknockout mice appear to be embryonic lethal, however, typical male infertility phenotypic features such as abnormal fetal testi...
To conclude, we identified de novo missense and likely gene-disrupting variants in the E3-ubiquitin ligase FBXO11 in individuals with a neurodevelopmental disorder comprising a variable degree of intellectual disability and various other features. Declaration of Interests I.E.S. has served on scientif...
[36] “If an employee causes an accident by intentional and willful misbehavior, but the accident does not result in major disability or death, the employee is not entitled to compensation. A degree of permanent disability of at...
Background and aims Interrupting ongoing activities with the intention to resume them again later is a natural response to pain. However, such interruptions might have negative consequences for the subsequent resumption and performance of the interrupted
Through the use of the threat of a suit under the Americans with Disability Act, Lancaster had recently been forced to install curb cuts at a cost of close to $3 million. Bringing this suit had burned some valuable social capital with the city’s officials who were under constant pressure ...
Financial Decisions of Households Financial Decisions of Firms Forms of Business Organization Separation of Ownership and Management The Goal of Management Market Discipline: Takeovers The Role of the Finance Specialist in a Corporation Summarytc "Summary" Finance is the study of how to allocate scarce...
Intellectual DisabilityPeople with intellectual disability form one of the largest single disability groups in a community. Intellectual disability refers to a general slowness to learn and function within society, and the identification of intellectual disability is usually based on an assessment of a pe...