他们发现DDX3Y蛋白的N端内在无序序列(intrinsically disordered region,IDR)相比于DDX3X的N端内在无序序列能更强的促进其液-液相分离;DDX3Y的腺苷三磷酸酶活性(ATPase)比DDX3X低,并且这一活性差异造成DDX3Y的液-液相分离聚集体更加缓慢的解聚;D...
RNA解旋酶DDX3X和DDX3Y就是这样一对分别由X和Y染色体编码的同源蛋白,对其功能差异的研究将有助于人们更好的理解RNA代谢和人类疾病上的性别差异。 2022年5月18日,来自宾夕法尼亚大学Perelman医学院Kathy Liu团队的沈辉博士和博士生Amber Yanas共同一作在Molecular Cell杂志上发表了一篇题为Sexually dimorphic RNA heli...
MYCDDX3XDDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma but the fundoi:10.2139/ssrn.3520953Gong, ChunKrupka, JoannaGao, JieGrigoropoulos, Nicholas FrancisScreen, Michael...
DDX3X-linked conditions often exhibit sex differences, possibly due to differences between expression or function of the X- and Y-linked paralogs DDX3X and DDX3Y. DDX3X-related diseases have different mutational landscapes, indicating different roles of DDX3X. Understanding the role of DDX3X in ...
ActivAbTMAnti-DDX3X/DDX3Y Polyclonal Antibody 规格 50ul ; 100ul ; 20ul 宿主 Rabbit 克隆类型 Polyclonal Antibody 亚型 IgG 交叉反应 Human ; Mouse 预测交叉反应 Chimpanzee 应用 WB 稀释比例 WB 1:1000-3000. 靶标 DDX3X/DDX3Y 别名 DBX,DDX3,HLP2,DDX14,CAP-Rf,MRX102,DBY, DEAD (Asp-Glu-Ala...
DDX3X, the functional X homologue of the major AZFa gene, DDX3Y, belongs to the highly conserved PL10-subfamily of DEAD-box RNA helicase genes which are functionally conserved from yeast to man. They are mainly involved in cell cycle control and translation initiation control of gene transcripts...
Co-expression of mCherry-tagged DDX3Y and each of the mClover3-tagged DDX3X mutants showed that, as with WT DDX3X, DDX3Y was recruited to the shells of each mutant’s hollow condensate (Fig. 6b). In our previous work, we found that condensates of DDX3Y (both in vitro and in cells...
gall bladder and other tissues. Among its related pathways are Innate Immune System and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. DDX3X is related to nucleic acid binding and RNA binding. DDX3Y is an important paralog of DDX3X gene. DDX3X is associated with some diseases, ...
Loss-of-function of DDX3X is a leading cause of neurodevelopmental disorders (NDD) in females. DDX3X is also a somatically mutated cancer driver gene proposed to have tumour promoting and suppressing effects. We perform saturation genome editing of DDX3X
DDX3Xand its homologueDDX3Y[3].DDX3X (DBX, DDX3)is located on p11.3–11.23 on the X chromosome and escapes X-inactivation in females [4,5]. It is expressed ubiquitously in human tissues and participates in many biological processes [2,6,7,8].DDX3Y (DBY)is located on the Y-...