摘要 Cyclic GMP-AMP synthase (cGAS) undergoes liquid-liquid phase separation (LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation, and the condensed cGAS colocalizes with stress granules (SGs). However, the molecular mechanism underlying the modulation of cGAS activatio...
Background Systemic lupus erythematosus (SLE) is an autoimmune disease with strong heterogeneity, leading to variable clinical symptoms, which makes diagnosis and activity evaluation difficult. Methods The original dataset of GSE88884 was analyzed to screen differentially expressed genes (DEGs)...
-lupus erythmatosus uvedermologic syndrome hyperpigmentation - letigo pigmented nevi postinflammatory erthema -hemorrahge: trauma, vasculitis, vasculopathy, coagulaopathy patch description flat, circle ...its a bigger macule 註冊即可顯示定義。完全免費!
Canis lupus familiaris (Domestic dog) Homo sapiens (Human) Mus musculus (House mouse) Rattus norvegicus (Rat) View additional product information Experiments from the literature Reactivity None Available Applications None Available Validations None available Dilutions None available Published images We ha...
Validations None provided Applications Enzyme-linked immunosorbent assay(ELISA) Immunofluorescence(IF) Western Blotting(WB) Reactivity Bos taurus(Bovine) Canis lupus familiaris(Domestic dog) Equus caballus(Horse) Homo sapiens(Human) Mus musculus(House mouse) ...
Lastly, DHX9 is anautoantigenassociated with the early stages of systemic lupus erythematosus and possibly with primary Sjögren’s syndrome[147,148]. In accord with high female-to-male incidence ratios in these two diseases, the expression of DHX9 has also been found to be higher in females...
Negative regulation of DDX41 is essential because excessive expression oftype I interferonsmay cause various pathological conditions, such assystemic lupus erythematosus[122], orlymphocyte apoptosisduringListeria monocytogenesinfection. Besides TRIM21, the complementanaphylatoxinsC3aandC5ahave also been reported...
et al. A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients. EMBO Mol. Med. 3, 142–152 (2011). Article CAS PubMed PubMed Central Google Scholar Pertel, T., Reinhard, C. & Luban, J. Vpx rescues HIV-1 transduction of ...
Ddx3x, located on the X chromosome, belongs to the DEAD box RNA helicase family. Ddx3x is previously implicated in RNA metabolism, cell cycle control, apoptosis, tumorigeneses and viral infections. In the process of exploring the role of ddx3x in the female predominance of systemic lupus eryt...
红斑狼疮(Systemic Lupus Erythematosus,简称SLE)是一种慢性自身免疫性疾病,其特点是免疫系统错误地攻击身体自身的组织和器官。这种疾病的影响范围广泛,可以影响皮肤、关节、肾脏、大脑、心脏和其他身体部位。狼疮的潜在危险红斑狼疮的危险在于它的不可预测性和潜在的器官损害。最严重的情况包括:肾脏受损(狼疮性肾炎):肾脏...