本发明公开了lncRNA DDIT4AS1的应用及乳腺癌诊断和治疗制剂.本发明发现沉默lncRNA DDIT4AS1可以抑制乳腺癌细胞的增殖,迁移等,同时沉默DDIT4AS1增强乳腺癌细胞对化疗药物紫杉醇,多柔比星,顺铂的敏感性;裸鼠成瘤实验进一步表明抑制DDIT4AS1表达增强了紫杉醇的抑癌效果.本发明为后期相关药物开发以及临床诊断和治疗提供了...
DDIT4-AS1DDIT4Escherichia coliNeuroinflammationMolecular Neurobiology - Our previous studies have shown that meningitic Escherichia coli can colonize the brain and cause neuroinflammation. Controlling the balance of inflammatory responses in...doi:10.1007/s12035-021-02690-6Yang, Bo...
DDIT4-AS1UPF1Chemoresistance is a major factor contributing to the poor prognosis of patients with pancreatic cancer, and cancer stemness is one of the most crucial factors associated with chemoresistance and a very promising direction for cancer treatment. However, the exact molecular mechanisms of ...
DDIT4PSMB8-AS1glioblastomamiR-22-3pGlioblastoma (GBM) is known to be one of the most fatal malignanies in central nerve system. Unfortunately, the therapies for glioblastoma still calls for further improvements. Increasing evidences have shown that the aberrant expression of long non-coding RNAs ...
NNT-AS1 modulates prostate cancer cell proliferation, apoptosis and migration through miR-496/DDIT4 axisdoi:10.1186/S12935-020-01505-3Changlei YaoXianghua ChengXiuquan GuoXulou LuFan BuYanfen XuBioMed Central