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Here we present crystal structures of the DDB1-CRBN complex bound to thalidomide, lenalidomide and pomalidomide. The structure establishes that CRBN is a substrate receptor within CRL4CRBN and enantioselectively binds IMiDs. Using an unbiased screen, we identified the homeobox transcription factor MEIS...
Here we present crystal structures of the DDB1–CRBN complex bound to thalidomide, lenalidomide and pomalidomide. The structure establishes that CRBN is a substrate receptor within CRL4CRBN and enantioselectively binds IMiDs. Using an unbiased screen, we identified the homeobox transcription factor ME...
重组HUMAN CRBN & DDB1 蛋白, N-STREP & C-HIS CBNumber: CB513752290 分子式: 分子量: 0 MOL File: Mol file 重组HUMAN CRBN & DDB1 蛋白, N-STREP & C-HIS化学性质 安全信息 重组HUMAN CRBN & DDB1 蛋白, N-STREP & C-HIS性质、用途与生产工艺 ...
Synonyms:Recombinant Human CRBN & DDB1 Protein, N-Strep & C-His CAS: MF: MW:0 EINECS: Mol File:Mol File Information Error Report Your Email: Browse by NationalityRecombinant Human CRBN & DDB1 Protein, N-Strep & C-HisSuppliersChina suppliers ...
P-309 ZnDDC, a novel CELMoD-like agent binding to DDB1-CRBN complex demonstrates significant synergism with BTZ and IMiDs and overcomes IMiDs resistance in myeloma cell lines and primary samplesdoi:10.1016/S2152-2650(23)01927-4Gowtham Rajendran...
Background CRBN, a target of thalidomide and IMiDs immunomodulatory agents lenalidomide (LEN) and pomalidomide (POM), is a component of the E3 ubiquitin cullin 4 ring ligase (CRL4) complex that also includes DDB1, Roc1, and Cul4. Two CRBN mutations have been reported in multiple myeloma (...
Inhibition of the CRBN-DDB1-CUL4-ROC1 E3 Ubiquitin Ligase Mediates the Anti-Proliferative and Immunomodulatory Properties of LenalidomideLenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, ...
Recombinant Human DDB1/CRBN Complex Protein, CF| 基本信息 更多信息 中文名称: 中文同义词: 英文名称: Recombinant Human DDB1/CRBN Complex Protein, CF 英文同义词: Recombinant Human DDB1/CRBN Complex Protein, CF CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览...
Recombinant Human CRBN & DDB1 Protein, N-Strep & C-His CBNumber: CB513752290 Molecular Formula: Molecular Weight: 0 MDL Number: MOL File: Mol file Request For Quotation Suppliers1 Recombinant Human CRBN & DDB1 Protein, N-Strep & C-His Preparation Products And Raw materials ...