lncRNA DCSTl-AS1miR-874-3p增殖凋亡背景长链非编码RNA(long non-coding RNA,lncRNA)在直肠癌(rectal cancer,RC)中异常表达并可能参与肿瘤发生及发展过程,lncRNA DCST1-AS1在肿瘤中表达上调,但其在RC发生及发展过程中的作用机制尚未阐明,假设lncRNA DCST1-AS1在RC细胞中表达水平升高,并可能促进肿瘤发生及发展....
DCST1-AS1miR-29b细胞增殖迁移侵袭目的检测DCST1-AS1在非小细胞肺癌中的表达,并探讨其对癌细胞恶性生物学行为的影响.方法收集65例非小细胞肺癌患者的癌组织及其癌旁组织,体外培养正常人支气管上皮细胞16HBE和非小细胞肺癌细胞系(A549,H1299,H1650和HCC827).RT-qPCR法检测组织和细胞中DCST1-AS1,miR-29b表达水平...
Overexpression of DCST1-AS1 resulted in increased cell proliferation. Moreover, Overexpression of DCST1-AS1 significantly reversed the inhibitory effects of miR-29b on cancer cell proliferation. Conclusion: DCST1-AS1 may downregulate miR-29b through methylation in GBM to promote cancer cell ...
宫颈鳞状细胞癌组织 LncRNA DCST1-AS1,LncRNA MCM3AP-AS1 表达与增殖侵袭基因和预后的关系doi:10.13241/j.cnki.pmb.2024.10.038Objective: To investigate the relationship between the expression of long noncoding ribonucleic acids(LncRNA)DCSTAMP domain 1antisense 1(DC...
DCST1-AS1 can directly target miR-874-3p. Furthermore, inhibition of miR-874-3p could effectively alleviate the effect of inhibition of DCST1-AS1 on proliferation, invasion and migration of cervical cancer cells. Conclusion: Inhibition of DCST1-AS1 suppressed the proliferation, migration and ...
目的 探索长链非编码RNA(LncRNA)DCST1-AS1结合果糖二磷酸醛缩酶A(fructose-bisphosphate aldolase A,ALDOA)对三阴性乳腺癌细胞(MDA-MB-231)侵袭的影响.方法 采用RNA pulldown试验,质谱分析和RNA免疫共沉淀试验检测并分析DCST1-AS1与ALDOA之间的相互作用;采用癌症基因组图集(The Cancer Genome Atlas,TCGA)中的侵袭性...
DCST1-AS1 was able to induce methylation of p53 promoter. P53 was markedly upregulated by the knockdown of DCST1-AS1, presenting a negative correlation. LncRNA DCST1-AS1 drives the malignant progression of pediatric AML through inducing methylation of the p53 promoter.Jian Wang...
LncRNA DCST1-AS1 regulated cell proliferation, migration, invasion and apoptosis in gastric cancer by targeting miR-605-3pSU, Y.-Z.CUI, M.-F.DU, J.SONG, B.European Review for Medical & Pharmacological Sciences