Ductal carcinoma in situ (DCIS) is a non-invasive type of breast cancer with highly variable potential of becoming invasive and affecting mortality. Currently, many patients with DCIS are overtreated due to the lack of specific biomarkers that distinguish low risk lesions from those with a higher...
1.Boyd NF, Martin LJ, Bronskill M, Yaffe MJ, Duric N, Minkin S. Breast tissue composition and susceptibility to breast cancer. J Natl Cancer Inst. 2010;102(16):1224-1237.(Q1 10.3) 2.Boyd N, Martin L, Stone J, Little L, ...
At present, the surgical methods for operable breast cancer include local tumor resection, conservative breast surgery, and total breast mastectomy. A large number of prospective studies have confirmed that local resection alon...
DCIS On The Rise; Breast Cancer Concerns In 1997 2,910 women were diagnosed with what are presumed to be precancerous cells (DCIS); and by 2002 this had grown to 3,800 women. Professor Tony Howell says that this rise is down to the success of the National Breast Screening Programmes an...
Local treatment of breast cancer At present, the surgical methods for operable breast cancer include local tumor resection, conservative breast surgery, and total breast mastectomy. A large number of prospective studies have confirmed that local resection alone is not sufficient for the treatment of D...
Thus, the presence of a DCIS component in patients with IDC is associated with favorable clinical characteristics and independently predicts improved OS. IDC+DCIS could be a useful prognostic factor for patients with breast cancer, particularly if treatment de-escalation is being considered for small ...
The results also showed that "treatment generally reduces the risk for invasive breast cancer for women with DCIS" and women who received more intensive treatment (such as mastectomy) had lower rates of IBC, the researchers noted. However, breast cancer experts approached for comment raised several...
2 SchnittSJ, Giuliano AE, Harris JR,et al, Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast CancerAnnals of Surgical Oncology.2014,21:(3)704–716 ...
DNA methylation changes associated with cancer-related genes become more pronounced at invasive breast cancer stage. Importantly, we identify invasive-only and DCIS-specific DNA methylation alterations that could potentially determine which lesions progress to invasive cancer and which could remain as pre-...
IDC causes and risk factors It’s not known exactly what causes each case of breast cancer. But we do know many of the risk factors for these cancers, including lifestyle, hormones, and family history. Normal breast cells can become cancerous because of changes (or mutations) in genes. Bu...