I did several test to check how the Fmoc deprotection take place...using piperidine (10 % and 20%) and also non-nucleophilic base DBU (2 %)...when I analyze by LC/MS I detect a new peak with the same intensity of the main product. It seems that is a side reaction...It has a...
Improved Fmoc-Solid Phase Synthesis of β-Amyloid Peptides Using DBU as Nα-Deprotection ReagentAlzeheimer's Disease (AD) is the most common form of dementia affecting society today. It is a neurodegenerative disease, the histopathological features of which include extracellular deposition of amyloid...