doi:US5008380 AGaetano PalladinoPeter MacDonaldEttore BigattiUSUS5008380 * 1988年11月9日 1991年4月16日 Sicor Societa 'Italiana Corticosteroidi S.P.A. Process for the conversion of daunorubicin into doxorubicin
Conversion of iron chelator prodrug 6.70 into iron chelator 6.71 Sign in to download full-size image Gianni et al.[212] showed that the iron–doxorubicin (6.15, X = OH) complex is more reactive than the iron–daunorubicin (6.15, X = H) complex because the hydroxymethyl ketone side chain ...
Conversion of Daunorobicin-HCl 1 to 4'-epi Doxorubicin-HCl 13 employing the trifluoroacetyl moiety for the 3'-amino group protection Methanolysis To a solution of 8 g (14 mmol) of daunorubicin-HCl 1 in 500 ml of dry MeOH, 5.9 ml (79 mmol, 5.6 eq.)of acetylchlooride was added. ...
Both IDR and DNR undergo conversion to their respective alcohol metabolites, 13-hydroxyidarubicin (idarubicin-ol [IDR-ol]) and daunorubicin-ol (DNR-ol); however, unlike DNR-ol, IDR-ol has a prolonged plasma phase.12, 13, 16 Speth et al have shown that DNR-ol disappears from the plasma ...
We postulate that OCT1 defects may contribute to the resistance of cancer cells treated with anthracyclines. Members of the anthracycline family such as doxorubicin (DOX) and daunorubicin (DNR) are hydrophilic anti- cancer agents that are transported into cells where they intercalate into the DNA,...
They are prepared from 4-demothoxy-daunomycinone or 2,3-dimethyl-4-methoxy-daunomycinone by condensation with an appropriate N-protected hexopyranosyl chloride and removal of the protecting group and, in the case X = OH, conversion of the 9-acetyl group to a 9-hydroxyacetyl group.SERU...
Process for conversion of daunorubicin into doxorubicin by the acidic hydrolysis of the oxalate ester of doxorubicin prepared from 14-bromo-daunorubicinAn improved process for the preparation of doxorubicin, by means of hydrolysis of a doxorubicin ester of a dicarboxylic acid, in acid medium....
They are prepared from 4-demothoxy-daunomycinone or 2,3-dimethyl-4-methoxy-daunomycinone by condensation with an appropriate N-protected hexopyranosyl chloride and removal of the protecting group and, in the case X = OH, conversion of the 9-acetyl group to a 9-hydroxyacetyl group.SERGIO...
ChemInform Abstract: MICROBIAL AND MAMMALIAN STEREOSELECTIVE CONVERSION OF 4‐DEMETHOXYDAUNORUBICIN TO THE CORRESPONDING 13‐(R)‐DIHYDRO DERIVATIVEantibioticsThe new anthracyclines 4-O-demethyl-11-deoxydoxorubicin, 4-O-demethyl-11-deoxydaunorubicin along with its 13-dihydro and 13-deoxo analogues are ...
conversiondaunorubicindoxorubicinShortageDue to a national shortage of daunorubicin we evaluated the effects of substituting doxorubicin 1:1 in the induction phase for adult patients with newly diagnosed acute lymphoblastic leukemia (ALL). We identified 10 patients receiving doxorubicin instead of daunorubicin...